ArticleAmerican journal of critical care : an official publication, American Association of Critical-Care Nurses2014
Interleukin 6 and apolipoprotein E as predictors of acute brain dysfunction and survival in critical care patients.
Article in American journal of critical care : an official publication, American Association of Critical-Care Nurses, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
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18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- A Systematic Review and Meta-Analysis of the Role of Peripheral Inflammation in Delirium.Brain and behavior · 2025Pooled it
- Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Biospecimens and Biomarkers.Neurocritical care · 2024Pooled it
- The complex interaction of genetics and delirium: a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2021Pooled it
- A systematic review of the overlap of fluid biomarkers in delirium and advanced cancer-related syndromes.BMC psychiatry · 2020Pooled it
- Trial
- Blood-based biomarkers and delirium in critically ill adults in the ICU: a systematic review.Intensive care medicine experimental · 2026Review
- Serum biomarkers of delirium in critical illness: a systematic review of mechanistic and diagnostic evidence.Intensive care medicine experimental · 2025Review
- Antipsychotic Use for ICU Delirium and Associated Inflammatory Markers.Journal of intensive care medicine · 2024Observational
- Meta-analysis of serological biomarkers at hospital admission for the likelihood of developing delirium during hospitalization.Frontiers in neurology · 2023Article
- Delirium risk factors in hospitalized patient: a comprehensive evaluation of underlying diseases and medications in different wards of a large Urban Hospital Center in Iran.BMC anesthesiology · 2022Observational
- The New Frontier of Perioperative Cognitive Medicine for Alzheimer's Disease and Related Dementias.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Platelet-to-lymphocyte ratio as a predictive index for delirium in critically ill patients: A retrospective observational study.Medicine · 2020Observational
- Biomarkers of Delirium Duration and Delirium Severity in the ICU.Critical care medicine · 2020Observational
- Apolipoprotein E genotype and the association between C-reactive protein and postoperative delirium: Importance of gene-protein interactions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Article
- Temporal biomarker profiles and their association with ICU acquired delirium: a cohort study.Critical care (London, England) · 2018Article
- Observational
- The American Geriatrics Society/National Institute on Aging Bedside-to-Bench Conference: Research Agenda on Delirium in Older Adults.Journal of the American Geriatrics Society · 2015Article
- Interleukin 6 and cognitive dysfunction.Metabolic brain disease · 2014Review
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7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDelirium occurs in up to 80% of intensive care patients and is associated with poor outcomes. The biological cause of delirium remains elusive.
objectivesTo determine if delirium and recovery are associated with serum levels of interleukins and apolipoprotein E over time and with apolipoprotein E genotype.
methodsThe sample consisted of 77 patients with no previous cognitive deficits who required mechanical ventilation for 24 to 96 hours. Daily serum samples were obtained for enzyme-linked immunosorbent assay measurements of interleukins 6, 8, and 10 and apolipoprotein E. DNA extracted from blood was analyzed for apolipoprotein E genotyping. The Confusion Assessment Method for the Intensive Care Unit was administered daily on days 2 through 9.
resultsAmong the 77 patients, 23% had no delirium, 46% experienced delirium, and 31% experienced coma. Additionally, 77% had delirium or coma (acute brain dysfunction), and compared with other patients, had fewer ventilator-free days (P = .03), longer stay (P = .04), higher care needs at discharge (P = .001), higher mortality (P = .02), and higher levels of interleukin 6 (P = .03), and the APOE*3/*3 apolipoprotein E genotype (P = .05). Serum levels of apolipoprotein E correlated with levels of interleukins 8 and 10. Patients with the E4 allele of apolipoprotein E had shorter duration of delirium (P = .02) and lower mortality (P = .03) than did patients without this allele.
conclusionsApolipoprotein E plays a complex role in illness response and recovery in critically ill patients. The relationship between apolipoprotein E genotype and brain dysfunction and survival is unclear.
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