ArticleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2014
Occurrence and transmission efficiencies of Borrelia burgdorferi ospC types in avian and mammalian wildlife.
Article in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 59 citations in OpenAlex.
- Curiouser and curiouser: understanding the intersection of inter- and intra-specific diversity during theInfection and immunity · 2026Review
- Polyvalent mRNA vaccine targeting outer surface protein C affords multi-strain protection against Lyme disease.NPJ vaccines · 2025Article
- Genetic landscape of Borrelia burgdorferi sensu stricto in Canada: a study of genetic diversity.Scientific reports · 2025Article
- Article
- Population dynamics of the Lyme disease bacterium, Borrelia burgdorferi, during rapid range expansion in New York State.Molecular ecology · 2024Article
- Tick-to-host transmission differs betweenMicrobiology spectrum · 2023Article
- Differential Resistance ofPathogens (Basel, Switzerland) · 2023Article
- Variation among strains of Borrelia burgdorferi in host tissue abundance and lifetime transmission determine the population strain structure in nature.PLoS pathogens · 2023Article
- Article
- Prevalence of Borrelia burgdorferi and diversity of its outer surface protein C (ospC) alleles in blacklegged ticks (Ixodes scapularis) in Delaware.Ticks and tick-borne diseases · 2023Article
- Phylogenomic Diversity Elucidates Mechanistic Insights into Lyme Borreliae-Host Association.mSystems · 2022Article
- Cellular and immunological mechanisms influence host-adapted phenotypes in a vector-borne microparasite.Proceedings. Biological sciences · 2022Article
- Local Community Composition Drives AvianVeterinary sciences · 2022Article
- Article
- A Borrelia burgdorferi outer surface protein C (OspC) genotyping method using Luminex technology.PloS one · 2022Article
- Exploring the Effects of Prescribed Fire on Tick Spread and Propagation in a Spatial Setting.Computational and mathematical methods in medicine · 2022Article
- Lyme Neuroborreliosis: Mechanisms ofBrain sciences · 2021Review
- Host Specialisation, Immune Cross-Reaction and the Composition of Communities of Co-circulating Borrelia Strains.Bulletin of mathematical biology · 2021Article
- The role of host phenology for parasite transmission.Theoretical ecology · 2021Article
- Lyme Disease in Humans.Current issues in molecular biology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Borrelia burgdorferi s.s., the bacterium that causes Lyme disease in North America, circulates among a suite of vertebrate hosts and their tick vector. The bacterium can be differentiated at the outer surface protein C (ospC) locus into 25 genotypes. Wildlife hosts can be infected with a suite of ospC types but knowledge on the transmission efficiencies of these naturally infected hosts to ticks is still lacking. To evaluate the occupancy and detection of ospC types in wildlife hosts, we adapted a likelihood-based species patch occupancy model to test for the occurrence probabilities (ψ - "occupancy") and transmission efficiencies (ε - "detection") of each ospC type. We detected differences in ospC occurrence and transmission efficiencies from the null models with HIS (human invasive strains) types A and K having the highest occurrence estimates, but both HIS and non-HIS types having high transmission efficiencies. We also examined ospC frequency patterns with respect to strains known to be invasive in humans across the host species and phylogenetic groups. We found that shrews and to a lesser extent, birds, were important host groups supporting relatively greater frequencies of HIS to non-HIS types. This novel method of simultaneously assessing occurrence and transmission of ospC types provides a powerful tool in assessing disease risk at the genotypic level in naturally infected wildlife hosts and offers the opportunity to examine disease risk at the community level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.