ArticleMetallomics : integrated biometal science2014
Enterococcus faecalis reconfigures its transcriptional regulatory network activation at different copper levels.
Article in Metallomics : integrated biometal science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- The iron paradox and particle size sensing: transcriptomic response ofApplied and environmental microbiology · 2026Article
- Reduced glutathione levels inmSystems · 2026Article
- Transcriptional regulatory network analysis identifies conserved cis-antisense ncRNAs in the vancomycin and ceftriaxone stress response ofFrontiers in molecular biosciences · 2026Article
- Identification of Multiple Iron Uptake Mechanisms in Enterococcus faecalis and Their Relationship to Virulence.Infection and immunity · 2023Article
- Article
- Adaptation to Adversity: the Intermingling of Stress Tolerance and Pathogenesis in Enterococci.Microbiology and molecular biology reviews : MMBR · 2019Review
- Copper stress in Staphylococcus aureus leads to adaptive changes in central carbon metabolism.Metallomics : integrated biometal science · 2019Article
- Integration of Biological Networks forFrontiers in molecular biosciences · 2019Article
- The Combined Effect of Cold and Copper Stresses on the Proliferation and Transcriptional Response ofFrontiers in microbiology · 2019Article
- Proteogenomic Analysis ofFrontiers in microbiology · 2018Article
- The Role of Fur in the Transcriptional and Iron Homeostatic Response ofFrontiers in microbiology · 2018Article
- Identification of Enterococcus faecalis enzymes with azoreductases and/or nitroreductase activity.BMC microbiology · 2017Article
- Stress Physiology of Lactic Acid Bacteria.Microbiology and molecular biology reviews : MMBR · 2016Review
- Different Transcriptional Responses from Slow and Fast Growth Rate Strains of Listeria monocytogenes Adapted to Low Temperature.Frontiers in microbiology · 2016Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
A global transcriptional regulatory network was generated in the pathogenic bacterium Enterococcus faecalis in order to understand how this organism can activate and coordinate its expression at different copper concentrations. The topological evaluation of the network showed common patterns described in other organisms. Integrating microarray experiments allowed the identification of two sub-networks activated at low (0.05 mM CuSO4) and high (0.5 mM CuSO4) concentrations of copper. The analysis indicates the presence of specific functionally activated modules induced by copper levels, highlighting the regulons LysR and ArgR as global regulators and CopY, Fur and LexA as local regulators. Taking advantage of the fact that E. faecalis presented a homeostatic module, we produced an in vivo intervention by removing this system from the cell without affecting the connectivity of the global transcriptional network. This strategy led us to find that this bacterium can reconfigure its gene expression to maintain cellular homeostasis, activating new modules principally related to glucose metabolism and transcriptional processes. Finally, these results position E. faecalis as the most complete and controllable systemic model organism for copper homeostasis available to date.
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