Evidence map›Paper›PMID 24382410›Full record

Trial reportCirculation. Arrhythmia and electrophysiology2014

A randomized controlled trial of catheter ablation versus medical treatment of atrial fibrillation in heart failure (the CAMTAF trial).

Ross J Hunter, Thomas J Berriman, Ihab Diab, Ravindu Kamdar, Laura Richmond, Victoria Baker, Farai Goromonzi, Vinit Sawhney, Edward Duncan, Stephen P Page and 7 more

4 registry-linked trialsAbstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Circulation. Arrhythmia and electrophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 237 papers, 27 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
237citing papers in PubMed, 27 pooled it
19.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01411371 naunknown statusnot on this map

Catheter Ablation Versus Medical Treatment of AF in Heart Failure

TypeinterventionalSponsorBarts & The London NHS TrustRan2005 to 2011Enrolled60ConditionsAtrial Fibrillation, Heart FailureArmsCatheter ablation of persistent atrial fibrillation, Medical treatment alone
NCT02509754 phase4unknown statusnot on this mapstarted 2016, after this paper: background citation

Atrial Fibrillation Ablation Compared to Rate Control Strategy in Patients With Recently Diagnosed Impaired Left Ventricular Function: a Multicenter, Randomized Controlled Trial

TypeinterventionalSponsorUniversity of Turin, ItalyRan2016 to 2017Enrolled180ConditionsPersistent Atrial Fibrillation, Congestive Heart Failure Due to Left Ventricular Systolic DysfunctionArmsAtrial fibrillation catheter ablation, Rate control
NCT04922281 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

Insertable Cardiac Monitor-Guided Early Intervention to Reduce Atrial Fibrillation Burden Following Catheter Ablation (ICM REDUCE-AF)

TypeinterventionalSponsorUniversity of RochesterRan2022 to 2026Enrolled120ConditionsAtrial Fibrillation, Cardiovascular Diseases, Heart Diseases, Arrhythmias, CardiacArmsInsertable Cardiac Monitor or external non-invasive LT-ECG patch
NCT04987723 nacompletednot on this mapstarted 2022, after this paper: background citation

A Mechanistic Exploratory Study of AF-induced Cardiac Dysfunction and Symptoms

TypeinterventionalSponsorBarts & The London NHS TrustRan2022 to 2024Enrolled106ConditionsAtrial Fibrillation, Heart FailureArmsHolter monitoring, stress echocardiography, Cardiac MRI, Patient questionnaires
3 · Its place in the literature

Who cites it

237 citing papers in PubMed, 27 syntheses or guidelines pooled it, 496 citations in OpenAlex.

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  10. Durability of pulmonary vein isolation for atrial fibrillation: a meta-analysis and systematic review.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
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  11. The impact of catheter ablation in patient's heart failure and atrial fibrillation: a meta-analysis of randomized clinical trials.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2023
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  13. Catheter ablation improves cardiovascular outcomes in patients with atrial fibrillation and heart failure: a meta-analysis of randomized controlled trials.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
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177 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Ross J HunterDepartment of Cardiology, St Bartholomew's Hospital, Bart's & The London NIHR Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Queen Mary, University of London, London, United Kingdom.
Thomas J Berriman
Ihab Diab
Ravindu Kamdar
Laura Richmond
Victoria Baker
Farai Goromonzi
Vinit Sawhney
Edward Duncan
Stephen P Page
Waqas Ullah
Beth Unsworth
Jamil Mayet
Mehul Dhinoja
Mark J Earley
Simon Sporton
Richard J Schilling
St Mary's Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRestoring sinus rhythm in patients with heart failure (HF) and atrial fibrillation (AF) may improve left ventricular (LV) function and HF symptoms. We sought to compare the effect of a catheter ablation strategy with that of a medical rate control strategy in patients with persistent AF and HF. METHODS AND

resultsPatients with persistent AF, symptomatic HF, and LV ejection fraction <50% were randomized to catheter ablation or medical rate control. The primary end-point was the difference between groups in LV ejection fraction at 6 months. Baseline LV ejection fraction was 32±8% in the ablation group and 34±12% in the medical group. Twenty-six patients underwent catheter ablation, and 24 patients were rate controlled. Freedom from AF was achieved in 21/26 (81%) at 6 months off antiarrhythmic drugs. LV ejection fraction at 6 months in the ablation group was 40±12% compared with 31±13% in the rate control group (P=0.015). Ablation was associated with better peak oxygen consumption (22±6 versus 18±6 mL/kg per minute; P=0.014) and Minnesota living with HF questionnaire score (24±22 versus 47±22; P=0.001) compared with rate control.

conclusionsCatheter ablation is effective in restoring sinus rhythm in selected patients with persistent AF and HF, and can improve LV function, functional capacity, and HF symptoms compared with rate control. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT01411371.

Indexed as

Catheter AblationAdultAgedAnti-Arrhythmia AgentsAtrial FibrillationFemaleHeart FailureHumansLondonMaleMiddle AgedOxygen ConsumptionQuality of LifeRecovery of FunctionRecurrenceStroke VolumeAnti-Arrhythmia Agentsatrial fibrillationcatheter ablationheart failure

Identifiers

PMID24382410
OpenAlexW2115347173

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.