ReviewFertility and sterility2014
Ovarian germline stem cells: an unlimited source of oocytes?
Review in Fertility and sterility, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02779374 (Autologous Bone Marrow Transplantation for Treatment of Premature Ovarian Insufficiency), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Autologous Bone Marrow Transplantation for Treatment of Premature Ovarian Insufficiency
Who cites it
20 citing papers in PubMed.
- Mesenchymal Stem Cells: A Therapeutic Approach in Fertility Restoration in Premature Ovarian Insufficiency.Stem cell reviews and reports · 2025Review
- Hippo Signaling in the Ovary: Emerging Roles in Development, Fertility, and Disease.Endocrine reviews · 2022Review
- Bloom syndrome helicase contributes to germ line development and longevity in zebrafish.Cell death & disease · 2022Article
- Articulating the "stem cell niche" paradigm through the lens of non-model aquatic invertebrates.BMC biology · 2022Review
- Appraisal of Experimental Methods to Manage Menopause and Infertility: Intraovarian Platelet-Rich Plasma vs. Condensed Platelet-Derived Cytokines.Medicina (Kaunas, Lithuania) · 2021Article
- Human Mesenchymal Stem Cell Therapy and Other Novel Treatment Approaches for Premature Ovarian Insufficiency.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- The Therapeutic Effect of Stem Cells on Chemotherapy-Induced Premature Ovarian Failure.Current molecular medicine · 2021Review
- Recent trends in stem cell therapy for premature ovarian insufficiency and its therapeutic potential: a review.Journal of ovarian research · 2020Review
- Vertebrate Lineages Exhibit Diverse Patterns of Transposable Element Regulation and Expression across Tissues.Genome biology and evolution · 2020Article
- Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity.Nature communications · 2020Article
- Autologous activated platelet-rich plasma injection into adult human ovary tissue: molecular mechanism, analysis, and discussion of reproductive response.Bioscience reports · 2019Review
- Expected advances in human fertility treatments and their likely translational consequences.Journal of translational medicine · 2018Review
- Observation of the influences of diosgenin on aging ovarian reserve and function in a mouse model.European journal of medical research · 2017Article
- Paternal programming of breast cancer risk in daughters in a rat model: opposing effects of animal- and plant-based high-fat diets.Breast cancer research : BCR · 2016Article
- CACN-1 is required in the Caenorhabditis elegans somatic gonad for proper oocyte development.Developmental biology · 2016Article
- Chemoablated mouse seminiferous tubular cells enriched for very small embryonic-like stem cells undergo spontaneous spermatogenesis in vitro.Reproductive biology and endocrinology : RB&E · 2015Article
- Genetics of gonadal stem cell renewal.Annual review of cell and developmental biology · 2015Review
- Making gametes from pluripotent stem cells--a promising role for very small embryonic-like stem cells.Reproductive biology and endocrinology : RB&E · 2014Article
- Ovarian adult stem cells: hope or pitfall?Journal of ovarian research · 2014Review
- Novel Approaches in Addressing Ovarian Insufficiency in 2019: Are We There Yet?Cell transplantationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
While there has been progress in directing the development of embryonic stem cells and induced pluripotent stem cells toward a germ cell state, their ability to serve as a source of functional oocytes in a clinically relevant model or situation has yet to be established. Recent studies suggest that the adult mammalian ovary is not endowed with a finite number of oocytes, but instead possesses stem cells that contribute to their renewal. The ability to isolate and promote the growth and development of such ovarian germline stem cells (GSCs) would provide a novel means to treat infertility in women. Although such ovarian GSCs are well characterized in nonmammalian model organisms, the findings that support the existence of adult ovarian GSCs in mammals have been met with considerable evidence that disputes their existence. This review details the lessons provided by model organisms that successfully utilize ovarian GSCs to allow for a continual and high level of female germ cell production throughout their life, with a specific focus on the cellular mechanisms involved in GSC self-renewal and oocyte development. Such an overview of the role that oogonial stem cells play in maintaining fertility in nonmammalian species serves as a backdrop for the data generated to date that supports or disputes the existence of GSCs in mammals as well as the future of this area of research in terms of its potential for any application in reproductive medicine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.