ArticleMedical hypotheses2014
Air pollution, inflammation and preterm birth: a potential mechanistic link.
Article in Medical hypotheses, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 7 syntheses or guidelines pooled it, 149 citations in OpenAlex.
- Noise pollution during pregnancy and congenital issues: systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- Oil and Gas Development and Adverse Birth Outcomes: A Qualitative and Quantitative Bias Analysis of the Epidemiologic Literature.Current environmental health reports · 2026Pooled it
- Impact of Maternal Demographic and Socioeconomic Factors on the Association Between Particulate Matter and Adverse Birth Outcomes: a Systematic Review and Meta-analysis.Journal of racial and ethnic health disparities · 2021Pooled it
- Impact of ambient air pollution on obesity: a systematic review.International journal of obesity (2005) · 2018Pooled it
- WHO Environmental Noise Guidelines for the European Region: A Systematic Review on Environmental Noise and Adverse Birth Outcomes.International journal of environmental research and public health · 2017Pooled it
- The association between fine particulate matter exposure during pregnancy and preterm birth: a meta-analysis.BMC pregnancy and childbirth · 2015Pooled it
- Ambient air pollution and adverse birth outcomes: a systematic review and meta-analysis.Journal of Zhejiang University. Science. BPooled it
- Article
- Perinatal exposure to gaseous pollutants and autism spectrum disorder in children: A nested case-control study in the nurses' health study ii cohort.Environmental science and pollution research international · 2026Article
- Association between ambient PMFrontiers in public health · 2026Article
- Machine learning-based prediction algorithm of spontaneous preterm birth using multi-source data.BMC pregnancy and childbirth · 2025Article
- Air pollution exposure during pregnancy and low birth weight and macrosomia: the role of gestational diabetes mellitus.Reproductive health · 2025Article
- Ambient Fine Particulate Matter, Residential Greenness, and Childhood Cancer Risk by Trimester of Exposure in Minnesota 2000 to 2014: A Case-Control Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Global, regional, and national burden of neonatal disorders and subtypes attributable to air pollution from 1990 to 2021: a systematic analysis of the Global Burden of Disease Study 2021.Journal of health, population, and nutrition · 2025Article
- Preventive Effects of Vanillic Acid Against Lung Inflammation and Oxidative Stress Induced by Dust Particles in Wistar Rats.Journal of cellular and molecular medicine · 2025Article
- The potential effect modifying role of nutrition, physical activity, and body mass index on the association between air pollution and adverse birth and early-life health outcomes: a scoping review.Environmental research communications · 2025Article
- Perinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988-2015).Environmental health : a global access science source · 2025Article
- The impact of environmental contaminants, air pollution, and social deprivation on childhood leukemia survival in California.Frontiers in oncology · 2025Article
- Review
- Long-term ambient sulfur dioxide exposure during gestation and preterm birth in North Carolina, 2003-2015.Atmospheric environment (Oxford, England : 1994) · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 7 institutions in 3 countries.
Funding
Abstract
Preterm birth is a public health issue of global significance, which may result in mortality during the perinatal period or may lead to major health and financial consequences due to lifelong impacts. Even though several risk factors for preterm birth have been identified, prevention efforts have failed to halt the increasing rates of preterm birth. Epidemiological studies have identified air pollution as an emerging potential risk factor for preterm birth. However, many studies were limited by study design and inadequate exposure assessment. Due to the ubiquitous nature of ambient air pollution and the potential public health significance of any role in causing preterm birth, a novel focus investigating possible causal mechanisms influenced by air pollution is therefore a global health priority. We hypothesize that air pollution may act together with other biological factors to induce systemic inflammation and influence the duration of pregnancy. Evaluation and testing of this hypothesis is currently being conducted in a prospective cohort study in Mexico City and will provide an understanding of the pathways that mediate the effects of air pollution on preterm birth. The important public health implication is that crucial steps in this mechanistic pathway can potentially be acted on early in pregnancy to reduce the risk of preterm birth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.