ArticleJournal of neuroendocrinology2014
Oestradiol alters central 5-HT1A receptor binding potential differences related to psychosocial stress but not differences related to 5-HTTLPR genotype in female rhesus monkeys.
Article in Journal of neuroendocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Impact of Tryptophan Depletion on Executive System Function during Menopause is Moderated by Childhood Adversity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Impact of early life adversity and tryptophan depletion on functional connectivity in menopausal women: A double-blind, placebo-controlled crossover study.Psychoneuroendocrinology · 2017Trial
- Medial prefrontal glutamate response to acute stress is associated with social subordination in female rhesus macaques.Translational psychiatry · 2025Article
- Alterations in adolescent brain serotonin (5HT)Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Sex influences the effects of social status on socioemotional behavior and serotonin neurochemistry in rhesus monkeys.Biology of sex differences · 2023Article
- Sex and social status modify the effects of fluoxetine on socioemotional behaviors in Syrian hamsters and rhesus macaques.Pharmacology, biochemistry, and behavior · 2022Article
- Behavioural and physiological plasticity in social hierarchies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Sex-dependent effects of social status on the regulation of arginine-vasopressin (AVP) V1a, oxytocin (OT), and serotonin (5-HT) 1A receptor binding and aggression in Syrian hamsters (Mesocricetus auratus).Hormones and behavior · 2021Article
- Diet matters: Glucocorticoid-related neuroadaptations associated with calorie intake in female rhesus monkeys.Psychoneuroendocrinology · 2018Article
- Socially Housed Female Macaques: a Translational Model for the Interaction of Chronic Stress and Estrogen in Aging.Current psychiatry reports · 2017Review
- Social change and access to a palatable diet produces differences in reward neurochemistry and appetite in female monkeys.Physiology & behavior · 2016Article
- Stress and the reproductive axis.Journal of neuroendocrinology · 2014Review
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11 authors at 2 institutions in 1 country.
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Abstract
Social subordination in female macaques represents a well-described model of chronic psychosocial stress. Additionally, a length polymorphism (5-HTTLPR) in the regulatory region of the serotonin (5-HT) transporter (5-HTT) gene (SLC6A4) is present in rhesus macaques, which has been linked to adverse outcomes similar to that described in humans with an analogous 5-HTTLPR polymorphism. The present study determined the effects of social status and the 5-HTTLPR genotype on 5-HT1A receptor binding potential (5-HT1A BP(ND)) in brain regions implicated in emotional regulation and stress reactivity in ovariectomised female monkeys, and then assessed how these effects were altered by 17β-oestradiol (E(2)) treatment. Areas analysed included the prefrontal cortex [anterior cingulate (ACC); medial prefrontal cortex (mPFC); dorsolateral prefrontal cortex; orbitofrontal prefrontal cortex], amygdala, hippocampus, hypothalamus and raphe nucleui. Positron emission tomography using p-[(18) F]MPPF was performed to determine the levels of 5-HT1A BP(ND) under a non-E(2) and a 3-week E(2) treatment condition. The short variant (s-variant) 5-HTTLPR genotype produced a significant reduction in 5-HT1A BP(ND) in the mPFC regardless of social status, and subordinate s-variant females showed a reduction in 5-HT1A BP(ND) within the ACC. Both these effects of 5-HTTLPR were unaffected by E(2). Additionally, E(2) reduced 5-HT1A BP(ND) in the dorsal raphe of all females irrespective of psychosocial stress or 5-HTTLPR genotype. Hippocampal 5-HT1A BP(ND) was attenuated in subordinate females regardless of 5-HTTLPR genotype during the non-E(2) condition, an effect that was normalised with E(2). Similarly, 5-HT1A BP(ND) in the hypothalamus was significantly lower in subordinate females regardless of 5-HTTLPR genotype, an effect reversed with E(2). Taken together, the data indicate that the effect of E(2) on modulation of central 5HT1A BP(ND) may only occur in brain regions that show no 5-HTTLPR genotype-linked control of 5-HT1A binding.
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