Synthesis and determination of chronic and acute thermal and chemical pain activities of a new derivative of phencyclidine in rats.

Abbas Ahmadi, Mohsen Khalili, Ramin Hajikhani, Leila Barghi, Farnaz Mihandoust

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In one paragraph

Article in Iranian journal of pharmaceutical research : IJPR, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 86% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Abbas Ahmadiepartment of Chemistry, Faculty of Science, Islamic Azad University, Karaj Branch, Karaj, Iran.

Mohsen KhaliliDepartment of Physiology, School of Medicine, Shahed University, Tehran, Iran.

Ramin Hajikhaniepartment of Chemistry, Faculty of Science, Islamic Azad University, Karaj Branch, Karaj, Iran.

Leila Barghiepartment of Chemistry, Faculty of Science, Islamic Azad University, Karaj Branch, Karaj, Iran.

Farnaz Mihandoustepartment of Chemistry, Faculty of Science, Islamic Azad University, Karaj Branch, Karaj, Iran.

Shahed University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain of this compound was determined using tail immersion test on rats and the results were compared with Ketamine and PCP. The results indicated a marked anti-nociception 2-25 min after ketamine injection, but the analgesic effect remained for 40 min following PCP-OCH3-tetralyl application in tail immersion test. However, the data obtained from formalin test showed that the chronic anti-nociception effect of ketamine was higher than PCP and PCP-OCH3-tetralyl exhibited almost similar analgesic effect.

Indexed as

1-Tetralone derivativesAcute and chronic painFormalin testKetaminePhencyclidineTail immersion test

Identifiers

PMID24381602

PMCPMC3870061

OpenAlexW2159838099

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.