Evidence map›Paper›PMID 24381592›Full record

ArticleAdvances in virology2013

Emergence of hepatitis B virus genotype f in aligarh region of north India.

Hiba Sami, Meher Rizvi, Mohd Azam, Rathindra M Mukherjee, Indu Shukla, M R Ajmal, Abida Malik

Abstract read
In one paragraph

Article in Advances in virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hiba SamiDepartment of Microbiology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh 202002, India.
Meher RizviDepartment of Microbiology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh 202002, India.
Mohd AzamDepartment of Microbiology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh 202002, India.
Rathindra M MukherjeeAsian Institute of Gastroenterology, Hyderabad 500082, India.
Indu ShuklaDepartment of Microbiology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh 202002, India.
M R AjmalDepartment of Medicine, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh 202002, India.
Abida MalikDepartment of Microbiology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh 202002, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction. HBV genotypes and subtypes are useful clinical and epidemiological markers. In this study prevalent HBV genotypes were assessed in relation to serological profile and clinical status. Material & Methods. 107 cases of HBV were genotyped. Detailed clinical history was elicited from them. HBsAg, HBeAg, anti-HBs, anti-HBe, and anti-HBc-IgM were assessed. HBV genotyping was performed using Kirschberg's type specific primers (TSP-PCR), heminested PCR, and Naito's monoplex PCR. Nucleotide sequencing was performed. Results. A total of 97 (91%) were genotyped following the methods of Kirschberg et al./Naito et al. Genotype D was by far the most prevalent genotype 91 (85.04%) in this region. A surprising finding was the detection of genotype F in 5 (4.67%) of our patients. Genotype A strangely was observed only in one case. In 85.7% genotype D was associated with moderate to severe liver disease, 43.9% HBeAg, and 18.7% anti-HBc-IgM positivity. Majority of genotype F (80%) was seen in mild to moderate liver disease. It was strongly associated with HBeAg 60% and 20% anti-HBc-IgM positivity. Conclusion. Emergence of genotype F in India merits further study regarding its clinical implications and treatment modalities. Knowledge about HBV genotypes can direct a clinician towards more informed management of HBV patients.

Identifiers

PMID24381592
PMCPMC3870090

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