ArticleFrontiers in microbiology2013
Proteomic responses of oceanic Synechococcus WH8102 to phosphate and zinc scarcity and cadmium additions.
Article in Frontiers in microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 65 citations in OpenAlex.
- Particulate Cadmium Accumulation in the Mesopelagic Ocean.Global biogeochemical cycles · 2025Article
- Dissolved organic phosphorus bond-class utilization by Synechococcus.FEMS microbiology ecology · 2024Article
- Proteome trait regulation of marine Synechococcus elemental stoichiometry under global change.The ISME journal · 2024Article
- Differentiated Zn(II) binding affinities in animal, plant, and bacterial metallothioneins define their zinc buffering capacity at physiological pZn.Metallomics : integrated biometal science · 2023Article
- A global ocean dissolved organic phosphorus concentration database (DOPv2021).Scientific data · 2022Article
- A single sensor controls large variations in zinc quotas in a marine cyanobacterium.Nature chemical biology · 2022Article
- Functional characterisation of substrate-binding proteins to address nutrient uptake in marine picocyanobacteria.Biochemical Society transactions · 2021Review
- Characterization of the metalloproteome of Pseudoalteromonas (BB2-AT2): biogeochemical underpinnings for zinc, manganese, cobalt, and nickel cycling in a ubiquitous marine heterotroph.Metallomics : integrated biometal science · 2021Article
- Progress and Challenges in Ocean Metaproteomics and Proposed Best Practices for Data Sharing.Journal of proteome research · 2019Review
- Transcriptional and Proteomic Choreography Under Phosphorus Deficiency and Re-supply in the NFrontiers in microbiology · 2019Article
- Iron limitation of microbial phosphorus acquisition in the tropical North Atlantic.Nature communications · 2017Article
- Extracellular Proteins: Novel Key Components of Metal Resistance in Cyanobacteria?Frontiers in microbiology · 2016Article
- Article
- Proteomic approaches in research of cyanobacterial photosynthesis.Photosynthesis research · 2015Review
- Functional distinctness in the exoproteomes of marine Synechococcus.Environmental microbiology · 2015Article
- Toward a systems-level understanding of gene regulatory, protein interaction, and metabolic networks in cyanobacteria.Frontiers in genetics · 2014Review
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Synechococcus sp. WH 8102 is a motile marine cyanobacterium isolated originally from the Sargasso Sea. To test the response of this organism to cadmium (Cd), generally considered a toxin, cultures were grown in a matrix of high and low zinc (Zn) and phosphate (PO4 (3-)) and were then exposed to an addition of 4.4 pM free Cd(2+) at mid-log phase and harvested after 24 h. Whereas Zn and PO4 (3-) had little effect on overall growth rates, in the final 24 h of the experiment three growth effects were noticed: (i) low PO4 (3-) treatments showed increased growth rates relative to high PO4 (3-) treatments, (ii) the Zn/high PO4 (3-) treatment appeared to enter stationary phase, and (iii) Cd increased growth rates further in both the low PO4 (3-) and Zn treatments. Global proteomic analysis revealed that: (i) Zn appeared to be critical to the PO4 (3-) response in this organism, (ii) bacterial metallothionein (SmtA) appears correlated with PO4 (3-) stress-associated proteins, (iii) Cd has the greatest influence on the proteome at low PO4 (3-) and Zn, (iv) Zn buffered the effects of Cd, and (v) in the presence of both replete PO4 (3-) and added Cd the proteome showed little response to the presence of Zn. Similar trends in alkaline phosphate (ALP) and SmtA suggest the possibility of a Zn supply system to provide Zn to ALP that involves SmtA. In addition, proteome results were consistent with a previous transcriptome study of PO4 (3-) stress (with replete Zn) in this organism, including the greater relative abundance of ALP (PhoA), ABC phosphate binding protein (PstS) and other proteins. Yet with no Zn in this proteome experiment the PO4 (3-) response was quite different including the greater relative abundance of five hypothetical proteins with no increase in PhoA or PstS, suggesting that Zn nutritional levels are connected to the PO4 (3-) response in this cyanobacterium. Alternate ALP PhoX (Ca) was found to be a low abundance protein, suggesting that PhoA (Zn, Mg) may be more environmentally relevant than PhoX.
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