ArticleCurrent neuropharmacology2013
Nature: a substantial source of auspicious substances with acetylcholinesterase inhibitory action.
Article in Current neuropharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Isolation, Identification and In Silico Evaluation of Novel Cholinesterase Inhibitors fromMolecules (Basel, Switzerland) · 2026Article
- Tanshinone I Ameliorates Psoriasis-Like Dermatitis by Suppressing Inflammation and Regulating Keratinocyte Differentiation.Drug design, development and therapy · 2025Article
- Assessing the toxic effects of bisphenol A in consumed crayfish Astacus leptodactylus using multi biochemical markers.Environmental science and pollution research international · 2022Article
- The Effect of Curcumin Nanoparticles on Cisplatin-Induced Cardiotoxicity in Male Wistar Albino Rats.Cardiovascular toxicology · 2021Article
- Article
- Natural Peptides in Drug Discovery Targeting Acetylcholinesterase.Molecules (Basel, Switzerland) · 2018Review
- Cholinesterases and the fine line between poison and remedy.Biochemical pharmacology · 2018Review
- Polypyridylruthenium(II) complexes exert in vitro and in vivo nematocidal activity and show significant inhibition of parasite acetylcholinesterases.International journal for parasitology. Drugs and drug resistance · 2018Article
- Chinese Herbal Medicine for Myasthenia Gravis: A Systematic Review and Meta-Analysis.Frontiers in pharmacology · 2018Article
- Polypyridylruthenium(II) complexes exert anti-schistosome activity and inhibit parasite acetylcholinesterases.PLoS neglected tropical diseases · 2017Article
- Anti-acetylcholinesterase activity and antioxidant properties of extracts and fractions of Carpolobia lutea.Pharmaceutical biology · 2017Article
- Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders.The journal of venomous animals and toxins including tropical diseases · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetylcholinesterase (AChE) (EC 3.1.1.7) is an important enzyme that breaks down of acetylcholine in synaptic cleft in neuronal junctions. Inhibition of AChE is associated with treatment of several diseases such as Alzheimer's disease (AD), myasthenia gravis, and glaucoma as well as the mechanisms of insecticide and anthelmintic drugs. Several AChE inhibitors are available in clinical use currently for the treatment of AD; however, none of them has ability, yet, to seize progress of the disease. Consequently, an extensive research has been going on finding new AChE inhibitors. In this sense, natural inhibitors have gained great attention due to their encouraging effects toward AChE. In this review, promising candidate molecules with marked AChE inhibition from both plant and animal sources will be underlined.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.