ArticleIndian journal of clinical biochemistry : IJCB2013
Mucosal IgA & IL-1β in Helicobacter pylori Infection.
Article in Indian journal of clinical biochemistry : IJCB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Correlation Between Interleukin-1β-511 C/T Polymorphism and Gastric Cancer in Chinese Populations: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2016Pooled it
- Development of a Recombinant Outer Membrane Vesicles (OMVs)-Based Vaccine Against Helicobacter pylori Infection in Mice.Journal of extracellular vesicles · 2025Article
- Evolution of immune and stromal cell states and ecotypes during gastric adenocarcinoma progression.Cancer cell · 2023Article
- Disruption of sncRNA Improves the Protective Efficacy of Outer Membrane Vesicles against Helicobacter pylori Infection in a Mouse Model.Infection and immunity · 2022Article
- TCDD exposure alters fecal IgA concentrations in male and female mice.BMC pharmacology & toxicology · 2022Article
- Impact of Coinfection with Schistosoma mansoni on the Antibody Response to Helicobacter pylori.Acta parasitologica · 2021Article
- Synthetic Lipopeptide Enhances Protective Immunity AgainstFrontiers in immunology · 2019Article
- Immunization with Heat Shock Protein A and γ-Glutamyl Transpeptidase Induces Reduction on the Helicobacter pylori Colonization in Mice.PloS one · 2015Article
- The Relation between Helicobacter pylori Infection and Acute Bacterial Diarrhea in Children.International journal of pediatrics · 2014Article
- Serum prolidase activity and oxidative stress in diabetic nephropathy and end stage renal disease: a correlative study with glucose and creatinine.Biochemistry research international · 2014Article
- Serum prolidase activity, oxidant and antioxidant status in nonulcer dyspepsia and healthy volunteers.ISRN biochemistry · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori infection stimulates strong local inflammatory and specific IgA antibody production. The influence of antibodies on the bacterial colonization is not clear. Here, we have analysed the association between the mucosal IgA level and IL-1β in various manifestations of the infection seen endoscopically. Antral biopsies of 57 dyspeptic patients were taken for culture, histology and estimation of mucosal levels of anti-H. pylori IgA and IL-1β. Mean mucosal IgA level was higher in patients with normal mucosa compared to all other groups and lower IgA level was associated with higher bacterial density. IL-1β was higher in ulcer patients and suspicious malignancy group as compared to normal group and higher level of IL-1β was associated with higher grades of metaplasia. Present study indicates that local immunity seems to have a protective role against H. pylori infection and higher level of IL-1β induced by the pathogen may be associated with metaplasia and carcinogenesis.
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