ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
ACF7 is a hair-bundle antecedent, positioned to integrate cuticular plate actin and somatic tubulin.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Global developmental delay and focal seizures in individuals with de novo truncating MACF1 variants.Human genomics · 2026Article
- BPAG1 promotes osteoclastogenesis and postmenopausal osteoporosis via activating ERK signaling pathway.iScience · 2025Article
- Microanatomy of the human tunnel of Corti structures and cochlear partition-tonotopic variations and transcellular signaling.Journal of anatomy · 2024Article
- The actin-bundling protein Fascin-1 modulates ciliary signalling.Journal of molecular cell biology · 2023Article
- A critical period of prehearing spontaneous CaThe EMBO journal · 2023Article
- Actin Crosslinking Family Protein 7 Deficiency Does Not Impair Hearing in Young Mice.Frontiers in cell and developmental biology · 2021Article
- Article
- Biomedical potential of mammalian spectraplakin proteins: Progress and prospect.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- A molecular basis for water motion detection by the mechanosensory lateral line of zebrafish.Nature communications · 2017Article
- Article
- Microtubule-actin crosslinking factor 1 (Macf1) domain function in Balbiani body dissociation and nuclear positioning.PLoS genetics · 2017Article
- Spectraplakin family proteins - cytoskeletal crosslinkers with versatile roles.Journal of cell science · 2017Review
- ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics.Nature communications · 2017Article
- MyTH4-FERM myosins in the assembly and maintenance of actin-based protrusions.Current opinion in cell biology · 2017Review
- Loss of MACF1 Abolishes Ciliogenesis and Disrupts Apicobasal Polarity Establishment in the Retina.Cell reports · 2016Article
- In vivo epidermal migration requires focal adhesion targeting of ACF7.Nature communications · 2016Article
- Supervillin Is a Component of the Hair Cell's Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells.PloS one · 2016Article
- The Stereociliary Paracrystal Is a Dynamic Cytoskeletal Scaffold In Vivo.Cell reports · 2015Article
- Knockdown of microtubule actin crosslinking factor 1 inhibits cell proliferation in MC3T3-E1 osteoblastic cells.BMB reports · 2015Article
- Relating structure and function of inner hair cell ribbon synapses.Cell and tissue research · 2015Review
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
The precise morphology of the mechanosensitive hair bundle requires seamless integration of actin and microtubule networks. Here, we identify Acf7a (actin crosslinking family protein 7a) as a protein positioned to bridge these distinct cytoskeletal networks in hair cells. By imaging Acf7a-Citrine fusion protein in zebrafish and immunolabeling of vestibular and cochlear mouse hair cells, we show that Acf7a and ACF7 circumscribe, underlie, and are interwoven into the cuticular plate (CP), and they also encircle the basal body of the kinocilium. In cochlear hair cells, ACF7 localization is graded, with the highest concentration near each fonticulus--an area free of F-actin in the region of the CP that contains the basal body. During hair-cell development and regeneration, Acf7a precedes formation of the hair bundle and CP. Finally, electron tomography demonstrates that the ends of microtubules insert into the CP and are decorated with filamentous linkers connecting microtubules to the CP. These observations are consistent with ACF7 being a linker protein, which may shape the cytoskeleton of the hair cell early during hair-bundle genesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.