ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Optogenetic activation of excitatory premotor interneurons is sufficient to generate coordinated locomotor activity in larval zebrafish.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 89 citations in OpenAlex.
- Redefining the central pattern generator for vertebrate locomotion.Nature reviews. Neuroscience · 2026Review
- Rebuilding spinal circuit function after spinal cord injury through a patient-specific interneuron precision model.Frontiers in neuroscience · 2026Article
- Activity-driven myelin sheath growth is mediated by mGluR5.Nature neuroscience · 2025Article
- Excitatory Spinal Lhx9-Derived Interneurons Modulate Locomotor Frequency in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Molecular blueprints for spinal circuit modules controlling locomotor speed in zebrafish.Nature neuroscience · 2024Article
- Spinal Interneurons: Diversity and Connectivity in Motor Control.Annual review of neuroscience · 2023Review
- Review
- Functional trajectories during innate spinal cord repair.Frontiers in molecular neuroscience · 2023Article
- Voltage imaging identifies spinal circuits that modulate locomotor adaptation in zebrafish.Neuron · 2022Article
- An injury-induced serotonergic neuron subpopulation contributes to axon regrowth and function restoration after spinal cord injury in zebrafish.Nature communications · 2021Article
- A specialized spinal circuit for command amplification and directionality during escape behavior.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Spinal V1 neurons inhibit motor targets locally and sensory targets distally.Current biology : CB · 2021Article
- Article
- Neural substrates involved in the cognitive information processing in teleost fish.Animal cognition · 2021Review
- Optogenetic approaches for understanding homeostatic and degenerative processes in Drosophila.Cellular and molecular life sciences : CMLS · 2021Review
- Repetitive optogenetic stimulation of glutamatergic neurons: An alternative to NMDA treatment for generating locomotor activity in spinalized zebrafish larvae.Physiological reports · 2021Article
- Article
- The Functional Role of Spinal Interneurons Following Traumatic Spinal Cord Injury.Frontiers in cellular neuroscience · 2020Article
- Critical Components for Spontaneous Activity and Rhythm Generation in Spinal Cord Circuits in Culture.Frontiers in cellular neuroscience · 2020Article
- Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural networks in the spinal cord can generate locomotion in the absence of rhythmic input from higher brain structures or sensory feedback because they contain an intrinsic source of excitation. However, the molecular identity of the spinal interneurons underlying the excitatory drive within the locomotor circuit has remained unclear. Using optogenetics, we show that activation of a molecularly defined class of ipsilateral premotor interneurons elicits locomotion. These interneurons represent the excitatory module of the locomotor networks and are sufficient to produce a coordinated swimming pattern in zebrafish. They correspond to the V2a interneuron class and express the transcription factor Chx10. They produce sufficient excitatory drive within the spinal networks to generate coordinated locomotor activity. Therefore, our results define the V2a interneurons as the excitatory module within the spinal locomotor networks that is sufficient to initiate and maintain locomotor activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.