ArticleJournal of geriatric psychiatry and neurology2014
Magnetic resonance imaging predictors of treatment response in late-life depression.
Article in Journal of geriatric psychiatry and neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Disruptive resting state networks characterizing depressive comorbidity in Alzheimer's disease and mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2025Pooled it
- Comparing the Symptomatology of Post-stroke Depression with Depression in the General Population: A Systematic Review.Neuropsychology review · 2024Pooled it
- Meta-analyses of the neural mechanisms and predictors of response to psychotherapy in depression and anxiety.Neuroscience and biobehavioral reviews · 2018Pooled it
- Influences of resting-state intrinsic functional brain connectivity on the antidepressant treatment response in late-life depression.Psychological medicine · 2023Trial
- Trajectories in Cerebral Blood Flow Following Antidepressant Treatment in Late-Life Depression: Support for the Vascular Depression Hypothesis.The Journal of clinical psychiatry · 2018Trial
- Moderators of treatment response in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Assessing remission in major depressive disorder using a functional-structural data fusion pipeline: A CAN-BIND-1 study.IBRO neuroscience reports · 2024Article
- The heterogeneity of late-life depression and its pathobiology: a brain network dysfunction disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- Influence and interaction of resting state functional magnetic resonance and tryptophan hydroxylase-2 methylation on short-term antidepressant drug response.BMC psychiatry · 2022Article
- Article
- Prediction of Antidepressant Efficacy by Cognitive Function in First-Episode Late-Life Depression: A Pilot Study.Frontiers in psychiatry · 2022Article
- Early-onset late-life depression: Association with body mass index, obesity, and treatment response.Comprehensive psychoneuroendocrinology · 2021Article
- Translational application of neuroimaging in major depressive disorder: a review of psychoradiological studies.Frontiers of medicine · 2021Review
- Neuroanatomical predictors of L-DOPA response in older adults with psychomotor slowing and depression: A pilot study.Journal of affective disorders · 2020Article
- Multidimensional imaging techniques for prediction of treatment response in major depressive disorder.Progress in neuro-psychopharmacology & biological psychiatry · 2019Article
- Neuroimaging of Small Vessel Disease in Late-Life Depression.Advances in experimental medicine and biology · 2019Article
- Depression Affects Intrinsic Brain Activity in Patients With Mild Cognitive Impairment.Frontiers in neuroscience · 2019Article
- Development and evaluation of a multimodal marker of major depressive disorder.Human brain mapping · 2018Article
- Intrinsic inter-network brain dysfunction correlates with symptom dimensions in late-life depression.Journal of psychiatric research · 2017Article
- Intrinsic functional connectivity in late-life depression: trajectories over the course of pharmacotherapy in remitters and non-remitters.Molecular psychiatry · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
In older adults, depression not only results in more years lived with disability than any other disease but it also carries additional risks of suicide, medical comorbidities, and family caregiving burden. Because it can take many months to identify an effective treatment regimen, it is of utmost importance to shorten the window of time and identify early on what medications and dosages will work effectively for individuals having depression. Late-life depression (LLD) has been associated with greater burden of age-related changes (eg, atrophy, white matter ischemic changes, and functional connectivity). Depression in midlife has been shown to alter affective reactivity and regulation, and functional magnetic resonance imaging (fMRI) studies in LLD have replicated the same abnormalities. Effective treatment can normalize these alterations. This article provides a review of the current literature using structural and functional neuroimaging to identify MRI predictors of treatment response in LLD. The majority of the literature on structural MRI has focused on the vascular depression hypothesis, and studies support the view that loss of brain volume and white matter integrity was associated with poorer treatment outcomes. Studies using fMRI have reported that lower task-based activity in the prefrontal cortex and limbic regions was associated with poorer outcome. These imaging markers may be integrated into clinical decision making to attain better treatment outcomes in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.