ArticlePlant physiology2014
SWEET17, a facilitative transporter, mediates fructose transport across the tonoplast of Arabidopsis roots and leaves.
Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.
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Who cites it
117 citing papers in PubMed, 281 citations in OpenAlex.
- The sugar transporter ZmSWEET11 participates in plant autophagy to respond to salt stress.GM crops & food · 2026Article
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- Integrated metabolomics and transcriptomics reveal sugar metabolism associated with cold tolerance in chrysanthemum.BMC plant biology · 2026Article
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2026Article
- Strigolactones Regulate Sugar Allocation to Control Rice Tillering and Root Development via the OsSPL14-OsSHR1-OsSWEET16 Pathway.Plant biotechnology journal · 2026Article
- SWEET1-mediated glucose transport is crucial for energy availability in Arabidopsis.The New phytologist · 2026Article
- Gaseous chlorine dioxide improves Keitt mango quality during postharvest ripening: enhancing sugar accumulation, terpenoid biosynthesis, and storage performance.Food chemistry. Molecular sciences · 2025Article
- Comprehensive Identification and Expression Analysis of thePlants (Basel, Switzerland) · 2025Article
- TheHorticulture research · 2025Article
- The SlDOF9-SlSWEET17 Module: a Switch for Controlling Sugar Distribution Between Nematode Induced Galls and Roots in Tomato.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- How vacuolar sugar transporters evolve and control cellular sugar homeostasis, organ development and crop yield.Nature plants · 2025Review
- Diet-regulated transcriptional plasticity of plant parasites in plant-mutualist environments.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genome-Wide Identification of the SWEET Gene Family and Functional Analysis ofInternational journal of molecular sciences · 2025Article
- Genetic Characterization ofPlants (Basel, Switzerland) · 2025Article
- Characterization of theInternational journal of molecular sciences · 2025Article
- The potato sugar transporter SWEET1g affects apoplasmic sugar ratio and phloem-mobile tuber- and flower-inducing signals.Plant physiology · 2024Article
- Comparative Transcriptome Analysis Reveals Mechanisms of Differential Salinity Tolerance BetweenGenes · 2024Article
- Genome wide identification of BjSWEET gene family and drought response analysis of BjSWEET12 and BjSWEET17 genes in Brassica juncea.BMC plant biology · 2024Article
- Indole-3-Acetic Acid (IAA) and Sugar Mediate Endosperm Development in Rice (Oryza sativa L.).Rice (New York, N.Y.) · 2024Article
- Symplasmic phloem loading and subcellular transport in storage roots are key factors for carbon allocation in cassava.Plant physiology · 2024Article
57 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fructose (Fru) is a major storage form of sugars found in vacuoles, yet the molecular regulation of vacuolar Fru transport is poorly studied. Although SWEET17 (for SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS17) has been characterized as a vacuolar Fru exporter in leaves, its expression in leaves is low. Here, RNA analysis and SWEET17-β-glucuronidase/-GREEN FLUORESCENT PROTEIN fusions expressed in Arabidopsis (Arabidopsis thaliana) reveal that SWEET17 is highly expressed in the cortex of roots and localizes to the tonoplast of root cells. Expression of SWEET17 in roots was inducible by Fru and darkness, treatments that activate accumulation and release of vacuolar Fru, respectively. Mutation and ectopic expression of SWEET17 led to increased and decreased root growth in the presence of Fru, respectively. Overexpression of SWEET17 specifically reduced the Fru content in leaves by 80% during cold stress. These results intimate that SWEET17 functions as a Fru-specific uniporter on the root tonoplast. Vacuoles overexpressing SWEET17 showed increased [14C]Fru uptake compared with the wild type. SWEET17-mediated Fru uptake was insensitive to ATP or treatment with NH4Cl or carbonyl cyanide m-chlorophenyl hydrazone, indicating that SWEET17 functions as an energy-independent facilitative carrier. The Arabidopsis genome contains a close paralog of SWEET17 in clade IV, SWEET16. The predominant expression of SWEET16 in root vacuoles and reduced root growth of mutants under Fru excess indicate that SWEET16 also functions as a vacuolar transporter in roots. We propose that in addition to a role in leaves, SWEET17 plays a key role in facilitating bidirectional Fru transport across the tonoplast of roots in response to metabolic demand to maintain cytosolic Fru homeostasis.
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