ArticleMolecular and cellular biochemistry2014
Overexpression of S100P promotes colorectal cancer metastasis and decreases chemosensitivity to 5-FU in vitro.
Article in Molecular and cellular biochemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Prognostic Value of S100P Expression in Patients With Digestive System Cancers: A Meta-Analysis.Frontiers in oncology · 2021Pooled it
- Role of S100 family proteins in colorectal cancer (CRC): an overview of their potential function as new biomarkers and therapeutic agents.Expert reviews in molecular medicine · 2025Review
- Single-cell RNA-sequencing uncovers the dynamic changes of tumour immune microenvironment in advanced lung adenocarcinoma.BMJ open respiratory research · 2023Article
- Analysis of RNA-Seq data using self-supervised learning for vital status prediction of colorectal cancer patients.BMC bioinformatics · 2023Article
- Biomarkers for Early Detection, Prognosis, and Therapeutics of Esophageal Cancers.International journal of molecular sciences · 2023Review
- Fluid Flow Stimulation Modulates Expression of S100 Genes in Normal Breast Epithelium and Breast Cancer.Cellular and molecular bioengineering · 2022Article
- A novel prognostic model based on urea cycle-related gene signature for colorectal cancer.Frontiers in surgery · 2022Article
- KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix.Molecular oncology · 2021Article
- S100P contributes to promoter demethylation and transcriptional activation of SLC2A5 to promote metastasis in colorectal cancer.British journal of cancer · 2021Article
- Development of prediction models for the sensitivity of oral squamous cell carcinomas to preoperative S-1 administration.Heliyon · 2020Article
- Friend or Foe: S100 Proteins in Cancer.Cancers · 2020Review
- An Integrated Bioinformatic Analysis of the S100 Gene Family for the Prognosis of Colorectal Cancer.BioMed research international · 2020Article
- Comparative proteomic analysis of human serum before and after liver transplantation using quantitative proteomics.Oncotarget · 2019Article
- 'Psoriasis 1' reduces psoriasis‑like skin inflammation by inhibiting the VDR‑mediated nuclear NF‑κB and STAT signaling pathways.Molecular medicine reports · 2018Article
- S100P enhances the motility and invasion of human trophoblast cell lines.Scientific reports · 2018Article
- Interplay between Trx-1 and S100P promotes colorectal cancer cell epithelial-mesenchymal transition by up-regulating S100A4 through AKT activation.Journal of cellular and molecular medicine · 2018Article
- Cancer-associated S100P protein binds and inactivates p53, permits therapy-induced senescence and supports chemoresistance.Oncotarget · 2016Article
- Role of S100 Proteins in Colorectal Carcinogenesis.Gastroenterology research and practice · 2016Review
- The life and works of S100P - from conception to cancer.American journal of cancer research · 2016Review
- S100P interacts with integrin α7 and increases cancer cell migration and invasion in lung cancer.Oncotarget · 2015Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
S100P has been shown to be overexpressed in various cancers and to have putative involvement in the metastatic process. However, Clinical and pathological significance of S100P expression in colorectal cancer still needs to be further studied. In the present study, the method of immunohistochemistry was utilized to investigate S100P protein expression in 91 cases of colorectal cancer. Also, the influence of ectopic expression of S100P on the biologic behavior in SW480 colorectal cancer cells was studied. We found that S100P expression of colorectal cancer tissue was significantly higher than that of normal colorectal mucosal tissues. S100P expression showed to be significantly correlated with clinical staging, lymph node metastasis and recurrence. Ectopic expression of S100P promotes SW480 cancer cells migration and invasion, decreases chemosensitivity to 5-FU in vitro. These findings suggested that S100P could serve as a promising candidate for colorectal cancer marker, prognostic indicator, and therapeutic target.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.