Observational studyWorld journal of surgery2014
Primary hyperparathyroidism: an analysis of failure of parathyroidectomy.
Observational study in World journal of surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Intraoperative parathyroid hormone assay benefits surgery for primary hyperparathyroidism when preoperative localisation is negative or not performed.Annals of the Royal College of Surgeons of England · 2026Article
- Predicting Tumor Volume in Primary Hyperparathyroidism From Preoperative Clinical Data.The Journal of clinical endocrinology and metabolism · 2025Article
- Primary hyperparathyroidism: predictors of sporadic multi-gland disease.Endocrine connections · 2024Review
- Primary hyperparathyroidism in pregnancy: experience of a tertiary centre.Surgery today · 2023Article
- Findings of pilot study following the implementation of point of care intraoperative PTH assay using whole blood during surgery for primary hyperparathyroidism.Frontiers in endocrinology · 2023Article
- Persistent and Recurrent Primary Hyperparathyroidism: Etiological Factors and Pre-Operative Evaluation.Sisli Etfal Hastanesi tip bulteni · 2023Review
- Case of Recurrent Primary Hyperparathyroidism, Congenital Granular Cell Tumor, and Aggressive Colorectal Cancer.Journal of the Endocrine Society · 2022Article
- Article
- A peculiar manifestation and clinical course of occult primary hyperparathyroidism: a case report.Acta bio-medica : Atenei Parmensis · 2021Article
- Parathyromatosis as a cause of recurrence primary hyperparathyroidism: A case report.International journal of surgery case reports · 2021Article
- WillEndocrine · 2021Review
- Parathyroidectomy Results in Primary Hyperparathyroidism: Analysis of the Results From a Single Center.Sisli Etfal Hastanesi tip bulteni · 2021Article
- Localization of Parathyroid Disease in Reoperative Patients with Primary Hyperparathyroidism.International journal of endocrinology · 2020Review
- Predictors of multiglandular disease in primary hyperparathyroidism.Langenbeck's archives of surgery · 2018Article
- Retropharyngeal Parathyroid Glands: Important Differences.World journal of surgery · 2018Article
- Is Unilateral Neck Surgery Feasible in Patients with Sporadic Primary Hyperparathyroidism and Double Negative Localisation?World journal of surgery · 2017Article
- Is C-11 Methionine PET/CT Able to Localise Sestamibi-Negative Parathyroid Adenomas?World journal of surgery · 2017Article
- Sporadic multiple parathyroid gland disease--a consensus report of the European Society of Endocrine Surgeons (ESES).Langenbeck's archives of surgery · 2015Review
- Patterns of disease in patients at a tertiary referral centre requiring reoperative parathyroidectomy.Annals of the Royal College of Surgeons of England · 2015Article
- Reoperations for persistent or recurrent primary hyperparathyroidism: results of a retrospective cohort study at a tertiary referral center.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreoperative imaging in patients undergoing surgery for primary hyperparathyroidism (PHPT) is used primarily to facilitate targeted parathyroidectomy. Failure of preoperative localisation mandates a bilateral exploration. It is thought that the results of imaging may also predict the success of surgery. The aims of this study were to assess whether the findings on preoperative localisation influenced outcomes following parathyroidectomy for PHPT and to explore factors underlying failure to cure at surgery.
methodsWe analysed outcomes of all patients who underwent first-time surgery for PHPT in two centres over a 5-year period to determine an association with demographic characteristics and findings on preoperative imaging. Records of patients not cured by initial surgery were reviewed to explore factors underlying failure to cure.
resultsThe failure rate (persistent disease) in the entire cohort was 5 % (25/541) (bilateral neck explorations, 5 %; unilateral exploration, 7 %; targeted approach, 4 %), while two patients developed recurrent disease. In patients who had undergone dual imaging with an ultrasound scan and (99m)Tc-sestamibi scintigraphy, failure rates with "lateralised and concordant" imaging, "nonconcordant" imaging, and "dual-negative" imaging were 2, 9, and 11 %, respectively (p = 0.01). Of the 25 patients with persistent disease, multigland disease (MGD) was present in 52 % (13/25) and ectopic adenoma in 24 % (6/12).
conclusionsPatients with PHPT who do not have lateralised and concordant dual imaging are at higher risk of persistent disease. A significant proportion of failures are due to the inability to recognise the presence and/or extent of MGD.
Indexed as
Identifiers
24381047What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.