ArticleCell transplantation2015
Engineering a fibrocartilage spectrum through modulation of aggregate redifferentiation.
Article in Cell transplantation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- The Effect of Neonatal, Juvenile, and Adult Donors on Rejuvenated Neocartilage Functional Properties.Tissue engineering. Part A · 2022Article
- Article
- Methodology to Quantify Collagen Subtypes and Crosslinks: Application in Minipig Cartilages.Cartilage · 2021Article
- 3D Bioprinted Implants for Cartilage Repair in Intervertebral Discs and Knee Menisci.Frontiers in bioengineering and biotechnology · 2021Review
- Engineering self-assembled neomenisci through combination of matrix augmentation and directional remodeling.Acta biomaterialia · 2020Article
- Enhancement of chondrogenic differentiation supplemented by a novel small compound for chondrocyte-based tissue engineering.Journal of experimental orthopaedics · 2020Article
- Surgical and tissue engineering strategies for articular cartilage and meniscus repair.Nature reviews. Rheumatology · 2019Review
- Remaining Hurdles for Tissue-Engineering the Temporomandibular Joint Disc.Trends in molecular medicine · 2019Review
- Tissue Engineering for the Temporomandibular Joint.Advanced healthcare materials · 2019Review
- Considerations for translation of tissue engineered fibrocartilage from bench to bedside.Journal of biomechanical engineering · 2018Article
- Tissue engineering toward temporomandibular joint disc regeneration.Science translational medicine · 2018Article
- Characterization of costal cartilage and its suitability as a cell source for articular cartilage tissue engineering.Journal of tissue engineering and regenerative medicine · 2018Article
- Using Costal Chondrocytes to Engineer Articular Cartilage with Applications of Passive Axial Compression and Bioactive Stimuli.Tissue engineering. Part A · 2018Article
- Functional self-assembled neocartilage as part of a biphasic osteochondral construct.PloS one · 2018Article
- The Self-Assembling Process and Applications in Tissue Engineering.Cold Spring Harbor perspectives in medicine · 2017Review
- Fibrochondrocyte Growth and Functionality on TiO₂ Nanothin Films.Journal of functional biomaterials · 2016Article
- Emergence of scaffold-free approaches for tissue engineering musculoskeletal cartilages.Annals of biomedical engineering · 2015Review
- Neocartilage integration in temporomandibular joint discs: physical and enzymatic methods.Journal of the Royal Society, Interface · 2015Article
- Harnessing biomechanics to develop cartilage regeneration strategies.Journal of biomechanical engineering · 2015Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Expanded costochondral cells provide a clinically relevant cell source for engineering both fibrous and hyaline articular cartilage. Expanding chondrocytes in a monolayer results in a shift toward a proliferative, fibroblastic phenotype. Three-dimensional aggregate culture may, however, be used to recover chondrogenic matrix production. This study sought to engineer a spectrum of fibrous to hyaline neocartilage from a single cell source by varying the duration of three-dimensional culture following expansion. In third passage porcine costochondral cells, the effects of aggregate culture duration were assessed after 0, 8, 11, 14, and 21 days of aggregate culture and after 4 subsequent weeks of neocartilage formation. Varying the duration of aggregate redifferentiation generated a spectrum of fibrous to hyaline neocartilage. Within 8 days of aggregation, proliferation ceased, and collagen and glycosaminoglycan production increased, compared with monolayer cells. In self-assembled neocartilage, type II-to-I collagen ratio increased with increasing aggregate duration, yet glycosaminoglycan content varied minimally. Notably, 14 days of aggregate redifferentiation increased collagen content by 25%, tensile modulus by over 110%, and compressive moduli by over 50%, compared with tissue formed in the absence of redifferentiation. A spectrum of fibrous to hyaline cartilage was generated using a single, clinically relevant cell source, improving the translational potential of engineered cartilage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.