Evidence map›Paper›PMID 24380079›Full record

ArticleBioMed research international2013

Toxicity and binding profile of lectins from the Genus canavalia on brine shrimp.

Francisco Vassiliepe Sousa Arruda, Arthur Alves Melo, Mayron Alves Vasconcelos, Romulo Farias Carneiro, Ito Liberato Barroso-Neto, Suzete Roberta Silva, Francisco Nascimento Pereira-Junior, Celso Shiniti Nagano, Kyria Santiago Nascimento, Edson Holanda Teixeira and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Novel Lectins fromACS omega · 2025
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Francisco Vassiliepe Sousa ArrudaIntegrated Laboratory of Biomolecules (LIBS-BioMol Group), Department of Pathology and Legal Medicine, Federal University of Ceará, 62042-280 Fortaleza, CE, Brazil.
Arthur Alves MeloLaboratory of Biologically Actives Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceará, 60440-970 Fortaleza, CE, Brazil.
Mayron Alves VasconcelosLaboratory of Biologically Actives Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceará, 60440-970 Fortaleza, CE, Brazil.
Romulo Farias CarneiroLaboratory of Biologically Actives Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceará, 60440-970 Fortaleza, CE, Brazil.
Ito Liberato Barroso-NetoLaboratory of Biologically Actives Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceará, 60440-970 Fortaleza, CE, Brazil.
Suzete Roberta SilvaMarine Biochemistry Laboratory, Fishing Engineering Department, Federal University of Ceará, 60440-970 Fortaleza, CE, Brazil.
Francisco Nascimento Pereira-JuniorLaboratory of Biologically Actives Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceará, 60440-970 Fortaleza, CE, Brazil.
Celso Shiniti NaganoMarine Biochemistry Laboratory, Fishing Engineering Department, Federal University of Ceará, 60440-970 Fortaleza, CE, Brazil.
Kyria Santiago NascimentoLaboratory of Biologically Actives Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceará, 60440-970 Fortaleza, CE, Brazil.
Edson Holanda TeixeiraIntegrated Laboratory of Biomolecules (LIBS-BioMol Group), Department of Pathology and Legal Medicine, Federal University of Ceará, 62042-280 Fortaleza, CE, Brazil.
Silvana Saker-SampaioMarine Biochemistry Laboratory, Fishing Engineering Department, Federal University of Ceará, 60440-970 Fortaleza, CE, Brazil.
Benildo Sousa CavadaLaboratory of Biologically Actives Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceará, 60440-970 Fortaleza, CE, Brazil.
Alexandre Holanda SampaioMarine Biochemistry Laboratory, Fishing Engineering Department, Federal University of Ceará, 60440-970 Fortaleza, CE, Brazil.
Universidade Federal do Ceará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lectins are sugar-binding proteins widely distributed in nature with many biological functions. Although many lectins have a remarkable biotechnological potential, some of them can be cytotoxic. Thus, the aim of this study was to assess the toxicity of five lectins, purified from seeds of different species of Canavalia genus. In order to determine the toxicity, assays with Artemia nauplii were performed. In addition, a fluorescence assay was carried out to evaluate the binding of lectins to Artemia nauplii. In order to verify the relationship between the structure of lectins and their cytotoxic effect, structural analysis was carried out to evaluate the volume of the carbohydrate recognition domain (CRD) of each lectin. The results showed that all lectins exhibited different toxicities and bound to a similar area in the digestive tract of Artemia nauplii. Concerning the structural analysis, differences in spatial arrangement and volume of CRD may explain the variation of the toxicity exhibited by each lectin. To this date, this is the first study that establishes a link between toxicity and structure of CRD from Diocleinae lectins.

Indexed as

Amino Acid SequenceAnimalsArtemiaCanavaliaCarbohydratesLectinsSeedsCarbohydratesLectins

Identifiers

PMID24380079
PMCPMC3860074
OpenAlexW2154368728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.