Evidence map›Paper›PMID 24380045›Full record

ArticleAmerican journal of nuclear medicine and molecular imaging2013

Myocardial blood flow measurement with a conventional dual-head SPECT/CT with spatiotemporal iterative reconstructions - a clinical feasibility study.

Fares Alhassen, Nhan Nguyen, Sukhkarn Bains, Robert G Gould, Youngho Seo, Stephen L Bacharach, Xiyun Song, Lingxiong Shao, Grant T Gullberg, Carina Mari Aparici

Abstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of nuclear medicine and molecular imaging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. A combined static-dynamic single-dose imaging protocol to compare quantitative dynamic SPECT with static conventional SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Article
  4. Advances in imaging instrumentation for nuclear cardiology.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Review
  5. Article
  6. Avoiding full corrections in dynamic SPECT images impacts the performance of SPECT myocardial blood flow quantitation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017
    Article
  7. Article
  8. Absolute myocardial blood flow quantification with SPECT/CT: is it possible?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fares AlhassenCenter for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA.
Nhan NguyenCenter for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA ; Nuclear Medicine Service, San Francisco Veterans Affairs Medical Center San Francisco, CA, USA.
Sukhkarn BainsCenter for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA.
Robert G GouldCenter for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA.
Youngho SeoCenter for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA.
Stephen L BacharachCenter for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA.
Xiyun SongPhilips Healthcare San Jose, CA, USA.
Lingxiong ShaoPhilips Healthcare San Jose, CA, USA.
Grant T GullbergCenter for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA ; Department of Radiotracer Development & Imaging Technology, Lawrence Berkeley National Laboratory Berkeley, CA, USA.
Carina Mari ApariciCenter for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA ; Department of Radiotracer Development & Imaging Technology, Lawrence Berkeley National Laboratory Berkeley, CA, USA.

Funding

DYNAMIC CARDIAC SPECT IMAGINGR01HL050663 · NHLBI · UNIVERSITY OF UTAH · PI GULLBERG, GRANT T · 1995 to 2014
$7.0M
NHLBI NIH HHS R01 HL050663
6 · The paper itself

Abstract

Cardiac single photon emission computed tomography (SPECT) cameras typically rotate too slowly around a patient to capture changes in the blood pool activity distribution and provide accurate kinetic parameters. A spatiotemporal iterative reconstruction method to overcome these limitations was investigated. Dynamic rest/stress (99m)Tc-methoxyisobutylisonitrile ((99m)Tc-MIBI) SPECT/CT was performed along with reference standard rest/stress dynamic positron emission tomography (PET/CT) (13)N-NH3 in five patients. The SPECT data were reconstructed using conventional and spatiotemporal iterative reconstruction methods. The spatiotemporal reconstruction yielded improved image quality, defined here as a statistically significant (p<0.01) 50% contrast enhancement. We did not observe a statistically significant difference between the correlations of the conventional and spatiotemporal SPECT myocardial uptake K 1 values with PET K 1 values (r=0.25, 0.88, respectively) (p<0.17). These results indicate the clinical feasibility of quantitative, dynamic SPECT/CT using (99m)Tc-MIBI and warrant further investigation. Spatiotemporal reconstruction clearly provides an advantage over a conventional reconstruction in computing K 1.

Indexed as

99mTc-MIBIDynamic SPECTmyocardial perfusion imagingspatiotemporal reconstructionSPECT/CTuptake rate constant

Identifiers

PMID24380045
PMCPMC3867729

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.