Evidence map›Paper›PMID 24379963›Full record

ArticleIranian journal of basic medical sciences2013

Teratogenic effects of pregabalin in mice.

Leila Etemad, Afshar Mohammad, Amir Hooshang Mohammadpour, Nasser Vahdati Mashhadi, Seyed Adel Moallem

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Iranian journal of basic medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Embryo-Fetal Developmental Toxicity Studies with Pregabalin in Mice and Rabbits.Birth defects research. Part B, Developmental and reproductive toxicology · 2016
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Leila EtemadPharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Afshar MohammadDepartment of Anatomy, Birjand University of Medical Sciences, Birjand, Iran ; Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Amir Hooshang MohammadpourPharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran ; Departments of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Nasser Vahdati MashhadiDepartments of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Seyed Adel MoallemPharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran ; Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

OBJECTIVE(S): Anti-epileptic drugs (AEDs) have the potential to affect fetal development throughout pregnancy. Considering the broad therapeutic indications of pregabalin (PGB), its potential teratogenic effects and the levels of homocysteine have been studied. MATERIALS AND

methodsTimed-pregnant mice received one of three doses of PGB (20, 40 or 80 mg/kg/day) or the vehicle control during organogenesis, intraperitoneally. The litters were stained and examined for malformations. Total homocysteine (tHcy) was measured in serum from the pregnant mice on GD18.

resultsThe rate of fetus malformations increased significantly in all treated groups as compared to the control group. The abnormalities included limb, vertebral column and craniofacial abnormalities. The most common abnormality was limb deformity. The percentage of fetal resorption significantly increased at higher doses. There was no significant difference in tHcy concentrations between the treated and control groups.

conclusionPregabalin may have potential teratogenic effects even in lower doses, however with less intensity than other AEDs. Therefore, it is suggested that great caution should be taken when prescribing it in pregnancy and further investigation for possible mechaninsms.

Indexed as

Antiepileptic drugsDevelopmental toxicityHomocysteineTeratogenicity

Identifiers

PMID24379963
PMCPMC3874092

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.