ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2013
Is prostatic adenocarcinoma in a relationship with Human Papilloma Virus in Isfahan -Iran.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Worldwide Prevalence of Human Papillomavirus and Relative Risk of Prostate Cancer: A Meta-analysis.Scientific reports · 2015Pooled it
- Human papillomavirus infection among men and its role in the etiology of prostate cancer: A prospective study.Central European journal of urology · 2025Article
- Does Human Papillomavirus Play a Causative Role in Prostate Cancer? A Systematic Review Using Bradford Hill's Criteria.Cancers · 2023Review
- Multiple pathogens and prostate cancer.Infectious agents and cancer · 2022Review
- Evidence for a causal role by human papillomaviruses in prostate cancer - a systematic review.Infectious agents and cancer · 2020Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProstatic adenocarcinoma is the most prevalent cancer and the second cause of cancer-related death among men. Human Papilloma Virus (HPV) considered as a preventable risk factor for prostatic adenocarcinoma. In this study, we detected the frequency of HPV infection in prostatic adenocarcinoma and benign prostatic hyperplasia (BPH) in Isfahan. MATERIALS AND
methodsIn this study, 120 paraffin-embedded blocks (90 and 30 cases with definite diagnosis of BPH and adenocarcinoma, respectively) were selected. Immunohistochemical (IHC) staining was performed for all selected blocks to detect HPV infection. The rate of infection was compared in the two studied groups.
resultsTotally, HPV was detected in four blocks. HPV infection was positive in 10% (3/30) of cases with adenocarcinoma and 1.1% (1/90) of cases with BPH (P = 0.04, OR = 9.88, CI 95%). Mean age of patients with positive and negative HPV infection was 61.75 ± 8.3 and 68.51 ± 11.7 years, respectively.
conclusionConsidering the higher prevalence of HPV infection in prostatic adenocarcinoma, it is suggested that HPV could be probable risk factor for prostatic adenocarcinoma. It is recommended to investigate the prevalence of HPV infection in Iranian men and the outcome of prevention and treatment of HPV infection on prostatic adenocarcinoma.
Indexed as
Identifiers
24379849PMC3872612W1575151392What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.