ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2013
Metoclopramide versus sumatriptan for treatment of migraine headache: A randomized clinical trial.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Pooled it
- Pain relief effect of metoclopramideGHM open · 2024Article
- Dopaminergic Projections from the Hypothalamic A11 Nucleus to the Spinal Trigeminal Nucleus Are Involved in Bidirectional Migraine Modulation.International journal of molecular sciences · 2023Article
- Pain reduction and adverse effects of intravenous metoclopramide for acute migraine attack: A systematic review and meta-analysis of randomized-controlled trials.World journal of methodology · 2022Article
- Trends in the Management of Headache Disorders in US Emergency Departments: Analysis of 2007-2018 National Hospital Ambulatory Medical Care Survey Data.Journal of clinical medicine · 2022Article
- Hypothalamic regulation of headache and migraine.Cephalalgia : an international journal of headache · 2019Review
- Current Approach to Undifferentiated Headache Management in the Emergency Department.Current pain and headache reports · 2019Review
- Single-dose intravenous sodium valproate (Depakine) versus dexamethasone for the treatment of acute migraine headache: a double-blind randomized clinical trial.Clinical and experimental emergency medicine · 2017Article
- Understanding migraine as a cycling brain syndrome: reviewing the evidence from functional imaging.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Review
- Effectiveness of the Concurrent Intravenous Injection of Dexamethasone and Metoclopramide for Pain Management in Patients with Primary Headaches Presenting to Emergency Department.Advanced journal of emergency medicine · 2017Article
- Comparison of Intravenous Metoclopramide and Acetaminophen in Primary Headaches: a Randomized Controlled Trial.Emergency (Tehran, Iran) · 2015Article
- Targeting TRP channels for novel migraine therapeutics.ACS chemical neuroscience · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are different options to manage benign headache in the emergency department. The costs, side effects, and efficacies of the drugs used are significantly different. The aim of this study was to compare intravenous (IV) metoclopramide with subcutaneous (SC) sumatriptan in treatment of migraine headache. MATERIAL AND
methodsIn a randomized, double-blinded clinical trial study, patients presenting to the university referral emergency department with acute benign headache were allocated into two groups after obtaining their informed consent. Patients received 20 mg of IV metoclopramide or 6 mg of SC sumatriptan. Pain intensity was assessed with 10-cm visual analog scale at baseline and 60 min after treatment.
resultsOne hundred and twenty-four subjects participated. The mean age was 34.9 ± 9 years in metoclopramide group and 26.8 ± 4 years in sumatriptan group (P < 0.0001). The baseline pain scores were 6.47 ± 0.84 and 6.12 ± 0.73 in metoclopramide and sumatriptan groups, respectively (P < 0.0001). The mean of pain score decreased to 0.66 ± 0.59 cm (P < 0.0001) in the metoclopramide group and 1.1 ± 0.70 (P < 0.0001) in the sumatriptan group. Comparison of these two groups showed more pain reduction in the metoclopramide group, with a mean difference of 0.55 ± 0.13 between the groups (95% CI: 0.25-0.79 cm) (P < 0.0001).
conclusionFor treatment of migraine headache, IV metoclopramide may be superior to SC sumatriptan in the emergency department.
Indexed as
Identifiers
24379846PMC3872609W2123804460What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.