ArticleFrontiers in genetics2013
Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans.
Article in Frontiers in genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- The association between genetic polymorphisms in ABCG2 and SLC2A9 and urate: an updated systematic review and meta-analysis.BMC medical genetics · 2020Pooled it
- Genome-wide association studies and traditional Chinese medicine in hyperuricemia: current evidence and mechanistic insights.Frontiers in pharmacology · 2025Review
- Support Provided by Caregivers for Community-Dwelling Obesity Individuals: Focus on Elderly and Hispanics.Healthcare (Basel, Switzerland) · 2023Article
- Novel and replicated clinical and genetic risk factors for toxicity from high-dose methotrexate in pediatric acute lymphoblastic leukemia.Pharmacotherapy · 2023Article
- Weak Association Between Genetic Markers of Hyperuricemia and Cardiorenal Outcomes: Insights From the STANISLAS Study Cohort With a 20-Year Follow-Up.Journal of the American Heart Association · 2022Article
- Novel risk factors for glucarpidase use in pediatric acute lymphoblastic leukemia: Hispanic ethnicity, age, and the ABCC4 gene.Pediatric blood & cancer · 2021Article
- Fine mapping and identification of serum urate loci in American Indians: The Strong Heart Family Study.Scientific reports · 2019Article
- Influence of Genetic and Non-Genetic Risk Factors for Serum Uric Acid Levels and Hyperuricemia in Mexicans.Nutrients · 2019Article
- Heterogeneity in Metabolic Responses to Dietary Fructose.Frontiers in genetics · 2019Review
- Renal hypouricemia caused by novel compound heterozygous mutations in the SLC22A12 gene: a case report with literature review.BMC medical genetics · 2018Article
- An update on the genetics of hyperuricaemia and gout.Nature reviews. Rheumatology · 2018Review
- ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study.Scientific reports · 2018Article
- Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane AAtherosclerosis · 2018Article
- Physiology of Hyperuricemia and Urate-Lowering Treatments.Frontiers in medicine · 2018Review
- The genetics of gout: towards personalised medicine?BMC medicine · 2017Review
- Genome-wide linkage and association analysis of cardiometabolic phenotypes in Hispanic Americans.Journal of human genetics · 2017Article
- Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study.BMC medical genetics · 2017Article
- Biological findings from the PheWAS catalog: focus on connective tissue-related disorders (pelvic floor dysfunction, abdominal hernia, varicose veins and hemorrhoids).Human genetics · 2016Article
- GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans.BMC genomics · 2016Article
- Genome-wide association of trajectories of systolic blood pressure change.BMC proceedings · 2016Article
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Authors and funding
17 authors at 3 institutions in 2 countries.
Funding
Abstract
Increased serum uric acid (SUA) is a risk factor for gout and renal and cardiovascular disease (CVD). The purpose of this study was to identify genetic factors that affect the variation in SUA in 632 Mexican Americans participants of the San Antonio Family Heart Study (SAFHS). A genome-wide association (GWA) analysis was performed using the Illumina Human Hap 550K single nucleotide polymorphism (SNP) microarray. We used a linear regression-based association test under an additive model of allelic effect, while accounting for non-independence among family members via a kinship variance component. All analyses were performed in the software package SOLAR. SNPs rs6832439, rs13131257, and rs737267 in solute carrier protein 2 family, member 9 (SLC2A9) were associated with SUA at genome-wide significance (p < 1.3 × 10(-7)). The minor alleles of these SNPs had frequencies of 36.2, 36.2, and 38.2%, respectively, and were associated with decreasing SUA levels. All of these SNPs were located in introns 3-7 of SLC2A9, the location of the previously reported associations in European populations. When analyzed for association with cardiovascular-renal disease risk factors, conditional on SLC2A9 SNPs strongly associated with SUA, significant associations were found for SLC2A9 SNPs with BMI, body weight, and waist circumference (p < 1.4 × 10(-3)) and suggestive associations with albumin-creatinine ratio and total antioxidant status (TAS). The SLC2A9 gene encodes an urate transporter that has considerable influence on variation in SUA. In addition to the primary association locus, suggestive evidence (p < 1.9 × 10(-6)) for joint linkage/association (JLA) was found at a previously-reported urate quantitative trait locus (Logarithm of odds score = 3.6) on 3p26.3. In summary, our GWAS extends and confirms the association of SLC2A9 with SUA for the first time in a Mexican American cohort and also shows for the first time its association with cardiovascular-renal disease risk factors.
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