ReviewFrontiers in immunology2013
The lymph self-antigen repertoire.
Review in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Role of the afferent lymph as an immunological conduit to analyze tissue antigenic and inflammatory load.Cell reports · 2024Article
- Lymphatic vessels in the age of cancer immunotherapy.Nature reviews. Cancer · 2024Review
- Mechanistic insight of curcumin: a potential pharmacological candidate for epilepsy.Frontiers in pharmacology · 2024Review
- Nanotechnologies for Physiology-Informed Drug Delivery to the Lymphatic System.Annual review of biomedical engineering · 2023Review
- Lung lymphatic thrombosis and dysfunction caused by cigarette smoke exposure precedes emphysema in mice.Scientific reports · 2022Article
- Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome.Frontiers in immunology · 2022Review
- Review
- Harnessing biomaterials for lymphatic system modulation.Acta biomaterialia · 2021Review
- Lymphedema alters lipolytic, lipogenic, immune and angiogenic properties of adipose tissue: a hypothesis-generating study in breast cancer survivors.Scientific reports · 2021Article
- Effects of functionally diverse calpain system on immune cells.Immunologic research · 2021Review
- Lymphatic Cannulation for Lymph Sampling and Molecular Delivery.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients.The Journal of experimental medicine · 2019Article
- Contribution of the plasma and lymph Degradome and Peptidome to the MHC Ligandome.Immunogenetics · 2019Review
- In vitro model reveals a role for mechanical stretch in the remodeling response of lymphatic muscle cells.Microcirculation (New York, N.Y. : 1994) · 2019Article
- The Antigen Processing and Presentation Machinery in Lymphatic Endothelial Cells.Frontiers in immunology · 2019Review
- Lymphatic Vessel Network Structure and Physiology.Comprehensive Physiology · 2018Review
- Exploiting lymphatic vessels for immunomodulation: Rationale, opportunities, and challenges.Advanced drug delivery reviews · 2017Review
- The Lymphatic System: Integral Roles in Immunity.Annual review of immunology · 2017Review
- Myocardial aging as a T-cell-mediated phenomenon.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Creation of an engineered APC system to explore and optimize the presentation of immunodominant peptides of major allergens.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The lymphatic fluid originates from the interstitial fluid which bathes every parenchymal organ and reflects the "omic" composition of the tissue from which it originates in its physiological or pathological signature. Several recent proteomic analyses have mapped the proteome-degradome and peptidome of this immunologically relevant fluid pointing to the lymph as an important source of tissue-derived self-antigens. A vast array of lymph-circulating peptides have been mapped deriving from a variety of processing pathways including caspases, cathepsins, MMPs, ADAMs, kallikreins, calpains, and granzymes, among others. These self peptides can be directly loaded on circulatory dendritic cells and expand the self-antigenic repertoire available for central and peripheral tolerance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.