ReviewFrontiers in human neuroscience2013
Synaptic and cellular profile of neurons in the lateral habenula.
Review in Frontiers in human neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The disappointment centre of the brain gets exciting: a systematic review of habenula dysfunction in depression.Translational psychiatry · 2024Pooled it
- Mesohabenular glutamatergic regulation of the consequences of uncontrollable stress.bioRxiv : the preprint server for biology · 2026Article
- Effects of Electrical Stimulation and Lidocaine Injection of Lateral Habenula Nucleus in the Addicted Rats with Morphine Self-administration.Journal of medical signals and sensors · 2026Article
- Article
- Ultrastructural Localization of Glutamate Delta Receptor 1 in the Rodent and Primate Lateral Habenula.The Journal of comparative neurology · 2025Article
- Increased Metabolic Potential, Efficacy, and Safety of Emerging Treatments in Schizophrenia.CNS drugs · 2023Review
- Unravelling the Role of Habenula Subnuclei on Avoidance Response: Focus on Activation and Neuroinflammation.International journal of molecular sciences · 2023Article
- Sex differences in neuronal activation during aversion-resistant alcohol consumption.Alcohol, clinical & experimental research · 2023Article
- Effects of GABAResearch in pharmaceutical sciences · 2023Article
- Water deprivation induces hypoactivity in rats independently of oxytocin receptor signaling at the central amygdala.Frontiers in endocrinology · 2023Article
- Low Current Intensity Plus an Ineffective Dose of Morphine Affect Conditioning Place Preference Through Different Pathways in the Lateral Habenula.Advanced biomedical research · 2023Article
- Multi-level variations of lateral habenula in depression: A comprehensive review of current evidence.Frontiers in psychiatry · 2022Review
- Activation of AMPA Receptors in the Lateral Habenula Produces Anxiolytic Effects in a Rat Model of Parkinson's Disease.Frontiers in pharmacology · 2022Article
- Framework for internal sensation of pleasure using constraints from disparate findings in nucleus accumbens.World journal of psychiatry · 2021Article
- Acetaldehyde Excitation of Lateral Habenular Neurons via Multiple Cellular Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Multimodal Investigations of Reward Circuitry and Anhedonia in Adolescent Depression.Frontiers in psychiatry · 2021Review
- Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula.Neurobiology of stress · 2020Article
- The Emerging Role of LHb CaMKII in the Comorbidity of Depressive and Alcohol Use Disorders.International journal of molecular sciences · 2020Review
- Circuits and functions of the lateral habenula in health and in disease.Nature reviews. Neuroscience · 2020Review
- Activation of 5-HTBehavioural brain research · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lateral habenula (LHb) is emerging as a crucial structure capable of conveying rewarding and aversive information. Recent evidence indicates that a rapid increase in the activity of LHb neurons drives negative states and avoidance. Furthermore, the hyperexcitability of neurons in the LHb, especially those projecting to the midbrain, may represent an important cellular correlate for neuropsychiatric disorders like depression and drug addiction. Despite the recent insights regarding the implications of the LHb in the context of reward and aversion, the exact nature of the synaptic and cellular players regulating LHb neuronal functions remains largely unknown. Here we focus on the synaptic and cellular physiology of LHb neurons. First, we discuss the properties of excitatory transmission and the implications of glutamate receptors for long-term synaptic plasticity; second, we review the features of GABAergic transmission onto LHb neurons; and finally, we describe the contribution that neuromodulators such as dopamine (DA) and serotonin may have for LHb neuronal physiology. We relate these findings to the role that the LHb can play in processing aversive and rewarding stimuli, both in health and disease states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.