ArticleFrontiers in systems neuroscience2013
Phase-locking of epileptic spikes to ongoing delta oscillations in non-convulsive status epilepticus.
Article in Frontiers in systems neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 9 citations in OpenAlex.
- Relation between the phase-lag index and lagged coherence for assessing interactions in EEG and MEG data.Neuroimage. Reports · 2021Article
- Dynamics from seconds to hours in Hodgkin-Huxley model with time-dependent ion concentrations and buffer reservoirs.PLoS computational biology · 2014Article
- Rethinking the electrographical boundaries of status epilepticus: controversies and paradoxes of the ictal-interictal continuum.Frontiers in neurologyReview
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Authors and funding
4 authors at 1 institution in 2 countries.
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Abstract
The EEG of patients in non-convulsive status epilepticus (NCSE) often displays delta oscillations or generalized spike-wave discharges. In some patients, these delta oscillations coexist with intermittent epileptic spikes. In this study we verify the prediction of a computational model of the thalamo-cortical system that these spikes are phase-locked to the delta oscillations. We subsequently describe the physiological mechanism underlying this observation as suggested by the model. It is suggested that the spikes reflect inhibitory stochastic fluctuations in the input to thalamo-cortical relay neurons and phase-locking is a consequence of differential excitability of relay neurons over the delta cycle. Further analysis shows that the observed phase-locking can be regarded as a stochastic precursor of generalized spike-wave discharges. This study thus provides an explanation of intermittent spikes during delta oscillations in NCSE and might be generalized to other encephathologies in which delta activity can be observed.
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