ArticleClinical epidemiology2014
A prospective study of statin use and mortality among 67,385 blacks and whites in the Southeastern United States.
Article in Clinical epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- The association between statin use and endometrial cancer survival outcome: A meta-analysis.Medicine · 2018Pooled it
- Statin use and survival outcomes in endocrine-related gynecologic cancers: A systematic review and meta-analysis.Oncotarget · 2017Pooled it
- Impact of in-hospital statin use on mortality in COVID-19 patients from a majority African American population.Heart & lung : the journal of critical careTrial
- Black men's awareness of peripheral artery disease and acceptability of screening in barbershops: a qualitative analysis.BMC public health · 2023Article
- Findings of a Novel Barbershop-Based Peripheral Artery Disease Screening Program for Black Men.Journal of the American Heart Association · 2022Article
- Differences in Comorbidities Explain Black-White Disparities in Outcomes After Femoropopliteal Endovascular Intervention.Circulation · 2022Article
- All-Cause Mortality and Cardiovascular Death between Statins and Omega-3 Supplementation: A Meta-Analysis and Network Meta-Analysis from 55 Randomized Controlled Trials.Nutrients · 2020 · on this mapArticle
- Review
- Statin therapy and recurrent venous thromboembolism in the elderly: a prospective cohort study.Scientific reports · 2019Observational
- Interventions to Reduce Ethnic and Racial Disparities in Dyslipidemia Management.Current treatment options in cardiovascular medicine · 2019Review
- Statin Use and Breast Cancer Prognosis in Black and White Women.Hormones & cancer · 2018Article
- Subclinical Atherosclerosis, Statin Eligibility, and Outcomes in African American Individuals: The Jackson Heart Study.JAMA cardiology · 2017Article
- Dietary polyunsaturated fatty acids and incidence of end-stage renal disease in the Southern Community Cohort Study.BMC nephrology · 2016Article
- Dyslipidemia in Special Ethnic Populations.Endocrinology and metabolism clinics of North America · 2016Review
- Intake of polyunsaturated fat in relation to mortality among statin users and non-users in the Southern Community Cohort Study.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2015Article
- Dyslipidemia in special ethnic populations.Cardiology clinics · 2015Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThe primary objective of this study is to examine the race-specific associations between statin use and overall mortality, as well as cardiovascular and cancer mortality, among blacks and whites in the Southeastern United States (US). Little is known about these associations in blacks. PATIENTS AND
methodsThe Southern Community Cohort Study is an ongoing, prospective cohort study, which enrolled from 2002 through 2009 nearly 86,000 participants aged 40-79 years. We used Cox regression models to estimate race-specific hazard ratios (HRs) and 95% confidence intervals (CI) for overall and cause-specific mortality associated with statin use based on self-reported hypercholesterolemia and treatment at cohort entry. Mean age at cohort entry was 51.4 years in blacks (n=48,825) and 53.5 years in whites (n=18,560). Sixty-one percent of participants were women. Whites were more likely to have self-reported hypercholesterolemia (40% versus 27%, P<0.001), and to report being treated with either statins (52% versus 47%, P<0.001) or combination lipid therapy (9% versus 4%, P<0.001) compared with blacks, regardless of sex. During follow-up (median: 5.6 years) 5,199 participants died. Compared with untreated hypercholesterolemic individuals, statin use was associated with reduced all-cause mortality (adjusted HR [aHR] 0.86; 95% CI 0.77-0.95) and cardiovascular disease mortality overall (aHR 0.75; 95% CI 0.64-0.89) and among whites (aHR 0.67; 95% CI 0.50-0.90), blacks (aHR, 0.80; 95% CI 0.65-0.98), men (aHR 0.70; 95% CI 0.55-0.90), and women (aHR 0.79; 95% CI 0.63-0.99) (P>0.05 for race and sex interaction). Statin use was not associated with cancer mortality overall or in subgroup analyses.
conclusionRegardless of race or sex, self-reported statin use was linked to reduced all-cause and cardiovascular disease mortality. However, factors contributing to the modestly lower statin use and markedly lower prevalence of self-reported hypercholesterolemia among blacks remain to be determined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.