ArticleInternational journal of nanomedicine2013
Intradermal air pouch leukocytosis as an in vivo test for nanoparticles.
Article in International journal of nanomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- Anti-Inflammatory Activity ofPharmaceuticals (Basel, Switzerland) · 2023Article
- Analysis of Neutrophil Responses to Biological Exposures.Current protocols · 2023Article
- Antioxidative and Anti-Inflammatory Activities of Rosebud Extracts of Newly Crossbred Roses.Nutrients · 2023Article
- Inflammation at Site of Insulin Infusion Diminishes Glycemic Control.Journal of pharmaceutical sciences · 2022Article
- Chlorite-Oxidized Oxyamylose (COAM) Has Antibacterial Activity and Positively Affects Skin Wound Healing.Journal of inflammation research · 2022Article
- Aloperine Ameliorates IMQ-Induced Psoriasis by Attenuating Th17 Differentiation and Facilitating Their Conversion to Treg.Frontiers in pharmacology · 2022Article
- A mouse air pouch model for evaluating the anti-bacterial efficacy of phage MR-5 in resolving skin and soft tissue infection induced by methicillin-resistant Staphylococcus aureus.Folia microbiologica · 2021Article
- Recombinant Protein-Based Nanoparticles: Elucidating their Inflammatory Effects In Vivo and their Potential as a New Therapeutic Format.Pharmaceutics · 2020Article
- The Biological Potential Hidden in Inclusion Bodies.Pharmaceutics · 2020Article
- MMP-9/Gelatinase B Degrades Immune Complexes in Systemic Lupus Erythematosus.Frontiers in immunology · 2019Article
- Evaluation of the in vitro and in vivo proinflammatory activities of gold (+) and gold (-) nanoparticles.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Article
- Synthesis and functionalization of protease-activated nanoparticles with tissue plasminogen activator peptides as targeting moiety and diagnostic tool for pancreatic cancer.Journal of nanobiotechnology · 2016Article
- In vivo proinflammatory activity of generations 0-3 (G0-G3) polyamidoamine (PAMAM) nanoparticles.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Etanercept administration prevents the inflammatory response induced by carrageenan in the murine air pouch model.Naunyn-Schmiedeberg's archives of pharmacology · 2015Article
- Preparation, characterization, and safety evaluation of poly(lactide-co-glycolide) nanoparticles for protein delivery into macrophages.International journal of nanomedicine · 2015Article
- Using the air pouch model for assessing in vivo inflammatory activity of nanoparticles.International journal of nanomedicine · 2014Article
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18 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The need for test systems for nanoparticle biocompatibility, toxicity, and inflammatory or adaptive immunological responses is paramount. Nanoparticles should be free of microbiological and chemical contaminants, and devoid of toxicity. Nevertheless, in the absence of contamination, these particles may still induce undesired immunological effects in vivo, such as enhanced autoimmunity, hypersensitivity reactions, and fibrosis. Here we show that artificial particles of specific sizes affect immune cell recruitment as tested in a dermal air pouch model in mice. In addition, we demonstrate that the composition of nanoparticles may influence immune cell recruitment in vivo. Aside from biophysical characterizations in terms of hydrodynamic diameter, zeta potential, concentration, and atomic concentration of metals, we show that - after first-line in vitro assays - characterization of cellular and molecular effects by dermal air pouch analysis is straightforward and should be included in the quality control of nanoparticles. We demonstrate this for innate immunological effects such as neutrophil recruitment and the production of immune-modulating matrix metalloproteases such as MMP-9; we propose the use of air pouch leukocytosis analysis as a future standard assay.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.