ReviewWorld journal of gastroenterology2013
Hepatitis C virus-related mixed cryoglobulinemia: is genetics to blame?
Review in World journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Cryoglobulinemia: An update on classification, pathophysiology, clinical presentation, and management.Journal of internal medicine · 2026Review
- Serological and Molecular Characterization of Hepatitis C Virus-Related Cryoglobulinemic Vasculitis in Patients without Cryoprecipitate.International journal of molecular sciences · 2023Article
- B-cell activating factor (BAFF), BAFF promoter and BAFF receptor allelic variants in hepatitis C virus related Cryoglobulinemic Vasculitis and Non-Hodgkin's Lymphoma.Hematological oncology · 2022Article
- Hematological and Genetic Markers in the Rational Approach to Patients With HCV Sustained Virological Response With or Without Persisting Cryoglobulinemic Vasculitis.Hepatology (Baltimore, Md.) · 2021Article
- Hepatitis C virus antibodies in outpatients with chronic kidney disease.Clinical and experimental hepatology · 2018Article
- Notch4 and mhc class II polymorphisms are associated with hcv-related benign and malignant lymphoproliferative diseases.Oncotarget · 2017Article
- Epidemiology of hepatitis C virus in Iran.World journal of gastroenterology · 2015Review
- Deregulation of microRNA expression in peripheral blood mononuclear cells from patients with HCV-related malignancies.Hepatology international · 2015Article
- Liver fibrosis occurs through dysregulation of MyD88-dependent innate B-cell activity.Hepatology (Baltimore, Md.) · 2015Article
- Association of BAFF -871C/T Promoter Polymorphism with Hepatitis C-Related Mixed Cryoglobulinemia in a Cohort of Egyptian Patients.Molecular diagnosis & therapy · 2015Article
- Cryoglobulinaemia in Egyptian Patients with Extrahepatic Cutaneous Manifestations of Chronic Hepatitis C Virus Infection.Dermatology research and practice · 2015Article
- Particularities of Renal Manifestations in Chronic Viral Hepatitis.Current health sciences journalArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mixed cryoglobulinemia (MC) is the extrahepatic manifestation most strictly correlated with hepatitis C virus (HCV) infection; it is a benign autoimmune and lymphoproliferative disorder that evolves to lymphoma in 5%-10% of cases. MC is reputed to be a multistep and multifactorial process whose pathogenicity is still poorly understood. It is still unknown why only some chronically infected HCV patients develop MC and only some of these exhibit systemic symptoms (MC syndrome). Several studies have investigated the pathogenetic basis of MC and the most recent ones suggest that the virus is able to trigger such a disorder only in the presence of genetic factors that are still unknown. Here, we try to clarify the complex relationship between HCV-related MC and the host's genetic background. The data that we report are heterogeneous and sometimes even conflicting. Therefore, large, multicenter studies are clearly needed. The identification of a characteristic genetic signature of cryoglobulinemic patients would be an important step toward a personalized approach in their clinical care. The new wide-ranging genomics technologies will hopefully help to resolve these complex issues.
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