ArticleWorld journal of gastroenterology2013
Association between TNF-α and IL-1β genotypes vs Helicobacter pylori infection in Indonesia.
Article in World journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Pooled it
- Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis.PloS one · 2016Pooled it
- A study on the antibacterial efficacy and action mechanism of clove againstFrontiers in pharmacology · 2026Article
- Article
- Differential cytokine expression in gastric tissues highlights helicobacter pylori's role in gastritis.Scientific reports · 2024Article
- Old and New Aspects ofChildren (Basel, Switzerland) · 2022Review
- First insights into the molecular basis association between promoter polymorphisms of the IL1B gene and Helicobacter pylori infection in the Sudanese population: computational approach.BMC microbiology · 2021Article
- The Influence ofThe application of clinical genetics · 2020Article
- Helicobacter pylori infection prevalence: Is it different in diabetics and nondiabetics?Indian journal of endocrinology and metabolismArticle
- Association of Interleukin-1B gene Polymorphism withPakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the correlation between the Helicobacter pylori (H. pylori) infection and host genetic background of healthy populations in Indonesia.
methodsIn March 2007, epidemiological studies were undertaken on the general population of a city in Indonesia (Mataram, Lombok). The participants included 107 men and 187 women, whose ages ranged from 6 to 74 years old, with an average age of 34.0 (± 14.4) (± SD). The H. pylori of subject by UBT method determination, and through the polymerase chain reaction with confronting two-pair primers (PCR-CTPP) method parsing the single nucleotide polymorphism of interleukin (IL)-8, IL-4, IL-1β, CD14, tumor necrosis factor (TNF-α) and tyrosine-protein phosphates non-receptor type 11 (PTPN11) genotypes. The experimental data were analyzed by the statistical software SAS.
resultsThe H. pylori infection rates in the healthy Indonesian population studied were 8.4% for men and 12.8% for women; no obvious differences were noted for H. pylori infection rates by sex or age. TC genotypes of IL-4, TC and CC genotypes of TNF-α, and GA genotypes of PTPN11, were higher in frequency. Both CC and TC genotype of TNF-α T-1031C loci featured higher expressions in the healthy Indonesian population Indonesia studied of (OR = 1.99; 95%CI: 0.67-5.89) and (OR = 1.66; 95%CI: 0.73-3.76), respectively. C allele of IL-1β T-31C gene locus was at a higher risk (OR = 1.11; 95%CI: 0.70-1.73) of H. pylori infection, but no statistical significance was found in our study.
conclusionWe reveal that the association between the TNF-α and IL-1β genotypes may be the susceptibility of H. pylori in the studied population.
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