ArticleProceedings of the National Academy of Sciences of the United States of America2014
Hemozoin-generated vapor nanobubbles for transdermal reagent- and needle-free detection of malaria.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Exploring the antimalarial potential of (+)-2,2'-epicytoskyrin A: in vitro and in vivo studies of a bioactive metabolite from endophytic fungus Diaporthe sp. GNBP-10.Malaria journal · 2026Article
- Advances in Malaria Diagnostic Methods in Resource-Limited Settings: A Systematic Review.Tropical medicine and infectious disease · 2024Review
- The Laboratory Diagnosis of Malaria: A Focus on the Diagnostic Assays in Non-Endemic Areas.International journal of molecular sciences · 2024Review
- Refractive Index of Single Surface Nanobubbles.Chemical & biomedical imaging · 2023Article
- Laser-induced nanobubbles safely ablate vitreous opacities in vivo.Nature nanotechnology · 2022Article
- Review of Microdevices for Hemozoin-Based Malaria Detection.Biosensors · 2022Review
- Acceptance and perceived value of non-invasive malaria diagnostic tests in malaria-endemic countries.Malaria journal · 2021Article
- A Lab-On-chip Tool for Rapid, Quantitative, and Stage-selective Diagnosis of Malaria.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- On-Chip Selective Capture and Detection of Magnetic Fingerprints of Malaria.Sensors (Basel, Switzerland) · 2020Article
- Evaluation of Malaria Diagnostic Methods as a Key for Successful Control and Elimination Programs.Tropical medicine and infectious disease · 2020Review
- Development of a quantitative, portable, and automated fluorescent blue-ray device-based malaria diagnostic equipment with an on-disc SiOScientific reports · 2020Article
- Rapid phenotyping towards personalized malaria medicine.Malaria journal · 2020Article
- Measuring the activation energy barrier for the nucleation of single nanosized vapor bubbles.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Hemozoin-catalyzed precipitation polymerization as an assay for malaria diagnosis.Nature communications · 2019Article
- Guided STED nanoscopy enables super-resolution imaging of blood stage malaria parasites.Scientific reports · 2019Article
- Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics.Chemical reviews · 2019Review
- Towards a needle-free diagnosis of malaria: in vivo identification and classification of red and white blood cells containing haemozoin.Malaria journal · 2017Article
- Reducing Uncertainty for Acute Febrile Illness in Resource-Limited Settings: The Current Diagnostic Landscape.The American journal of tropical medicine and hygiene · 2017Review
- The development of malaria diagnostic techniques: a review of the approaches with focus on dielectrophoretic and magnetophoretic methods.Malaria journal · 2016Review
- Efficient monitoring of the blood-stage infection in a malaria rodent model by the rotating-crystal magneto-optical method.Scientific reports · 2016Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
8 authors.
Funding
Abstract
Successful diagnosis, screening, and elimination of malaria critically depend on rapid and sensitive detection of this dangerous infection, preferably transdermally and without sophisticated reagents or blood drawing. Such diagnostic methods are not currently available. Here we show that the high optical absorbance and nanosize of endogenous heme nanoparticles called "hemozoin," a unique component of all blood-stage malaria parasites, generates a transient vapor nanobubble around hemozoin in response to a short and safe near-infrared picosecond laser pulse. The acoustic signals of these malaria-specific nanobubbles provided transdermal noninvasive and rapid detection of a malaria infection as low as 0.00034% in animals without using any reagents or drawing blood. These on-demand transient events have no analogs among current malaria markers and probes, can detect and screen malaria in seconds, and can be realized as a compact, easy-to-use, inexpensive, and safe field technology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.