ArticleInfection and immunity2014
Plasmodium berghei sporozoites acquire virulence and immunogenicity during mosquito hemocoel transit.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Histone modification analysis reveals common regulators of gene expression in liver and blood stage merozoites of Plasmodium parasites.Epigenetics & chromatin · 2023Article
- AnPathogens and global health · 2023Article
- Novel systems to study vector-pathogen interactions in malaria.Frontiers in cellular and infection microbiology · 2023Review
- Streamlining sporozoite isolation from mosquitoes by leveraging the dynamics of migration to the salivary glands.Malaria journal · 2022Article
- Inference and dynamic simulation of malaria using a simple climate-driven entomological model of malaria transmission.PLoS computational biology · 2022Article
- Dissection-independent production ofLife science alliance · 2021Article
- Transcriptional heterogeneity and tightly regulated changes in gene expression duringProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Genetic changes ofCurrent research in immunology · 2021Article
- Preparing for Transmission: Gene Regulation inFrontiers in cellular and infection microbiology · 2020Review
- Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites.Nature communications · 2019Article
- Article
- Important Extracellular Interactions between Plasmodium Sporozoites and Host Cells Required for Infection.Trends in parasitology · 2019Review
- The Liver-StageFrontiers in immunology · 2019Article
- Plasmodium Parasites Viewed through Proteomics.Trends in parasitology · 2018Review
- Non-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulence.Nature communications · 2018Article
- Review
- Experimental evaluation of cryopreservative solutions to maintain in vitro and in vivo infectivity of P. berghei sporozoites.PloS one · 2017Article
- Interaction betweenFrontiers in cellular and infection microbiology · 2017Article
- Palmitoyl transferases have critical roles in the development of mosquito and liver stages of Plasmodium.Cellular microbiology · 2016Article
- Comparative Plasmodium gene overexpression reveals distinct perturbation of sporozoite transmission by profilin.Molecular biology of the cell · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malaria is a vector-borne disease caused by the single-cell eukaryote Plasmodium. The infectious parasite forms are sporozoites, which originate from midgut-associated oocysts, where they eventually egress and reach the mosquito hemocoel. Sporozoites actively colonize the salivary glands in order to be transmitted to the mammalian host. Whether residence in the salivary glands provides distinct and vital cues for the development of infectivity remains unsolved. In this study, we systematically compared the infectivity of Plasmodium berghei sporozoites isolated from the mosquito hemocoel and salivary glands. Hemocoel sporozoites display a lower proportion of gliding motility but develop into liver stages when added to cultured hepatoma cells or after intravenous injection into mice. Mice infected by hemocoel sporozoites had blood infections similar to those induced by sporozoites liberated from salivary glands. These infected mice display indistinguishable systemic inflammatory cytokine responses and develop experimental cerebral malaria. When used as metabolically active, live attenuated vaccine, hemocoel sporozoites elicit substantial protection against sporozoite challenge infections. Collectively, these findings show that salivary gland colonization does not influence parasite virulence in the mammalian host when sporozoites are administered intravenously. This conclusion has important implications for in vitro sporozoite production and manufacturing of whole-sporozoite vaccines.
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