ArticleJournal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses
Fatigue in adolescents and young adults with sickle cell disease: biological and behavioral correlates and health-related quality of life.
Article in Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03291613 (PINPOINT), which is not on this map. Cited by 50 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PINPOINT: Gaming Technology to Engage Adolescent Sickle Cell Patients in Precision Pain Management
Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Measurement of fatigue in sickle cell disease: a systematic review of fatigue measures.Orphanet journal of rare diseases · 2025Pooled it
- Health-related quality of life in hemoglobinopathies: A systematic review from a global perspective.Frontiers in pediatrics · 2022Pooled it
- Safety and efficacy of monthly high-dose vitamin DEuropean journal of pediatrics · 2024Trial
- Patient-reported outcomes in sickle cell disease and association with clinical and psychosocial factors: Report from the sickle cell disease implementation consortium.American journal of hematology · 2020Trial
- Appraisal of patient-reported outcome measures in analogous diseases and recommendations for use in phase II and III clinical trials of pyruvate kinase deficiency.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Trial
- Vitamin D Supplementation Improves Health-Related Quality of Life and Physical Performance in Children with Sickle Cell Disease and in Healthy Children.Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & PractitionersTrial
- Frailty phenotype in adults with sickle cell disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Lived Experiences of Patients With Sickle Cell Disease and Kidney Failure: Insights From a Qualitative Study.Journal of patient experience · 2026Article
- "It's like going through life at a mediocre level": a qualitative study of the meaning and impact of fatigue in children and young people with sickle cell disease.BMC pediatrics · 2025Article
- Perceived stress and social support as correlates of sickle cell anaemia severity in a low-resource setting.BMC pediatrics · 2025Article
- Pain sensitisation in patients with sickle cell disease: A preliminary study.Journal of evaluation in clinical practice · 2025Article
- Elevated posterior insula glutamate in patients with sickle cell disease.The journal of pain · 2025Article
- Understanding stakeholders' experience with sickle cell disease by social media listening across Europe.Frontiers in genetics · 2025Article
- Recommended measurement protocols for sickle cell disease in the PhenX toolkit: psychosocial factors and social determinants of health.Journal of sickle cell disease · 2025Article
- Late effects of hemopoietic stem cell transplant for sickle cell disease: monitoring and management.Expert review of hematology · 2024Review
- Illness Intrusiveness in Adults with Sickle Cell Disease: The Role of Fatigue.Journal of clinical psychology in medical settings · 2023Article
- Patient-reported outcomes in children with sickle cell disease at presentation for an acute pain episode.Blood advances · 2023Article
- Article
- Fatigue, Stress Appraisal, and Emotional Functioning Among Youth With Sickle Cell Disease: A Daily Diary Study.Journal of pediatric psychology · 2023Article
- Sleep and fatigue among youth with sickle cell disease: A daily diary study.Journal of behavioral medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
This descriptive, correlational study examined fatigue and potential biological and behavioral correlates in adolescents and young adults with sickle cell disease. Sixty adolescents and young adults with sickle cell disease completed the Brief Fatigue Inventory, Multidimensional Fatigue Symptom Inventory-Short Form, Patient Reported Outcomes Measurement Information System (PROMIS) fatigue short form and measures of pain, sleep quality, anxiety, depressive mood, stress, disease severity, and quality of life. Blood samples were obtained for hemoglobin and cytokines. Fatigue scores were mostly moderate in severity. Fatigue interfered to a moderate degree with daily activities and correlated significantly with pain, sleep quality, state and trait anxiety, depressive mood, stress, and quality of life. Fatigue was correlated with hemoglobin on the PROMIS measure. Fatigue was not correlated with cytokines or age, nor differed by disease severity. Fatigue was common in these adolescents and young adults, interfered with daily activities such as school, work and exercise, and significantly correlated with several potentially modifiable factors. As life expectancy increases in sickle cell disease, research is needed to test interventions to reduce fatigue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.