Evidence map›Paper›PMID 24378638›Full record

ArticleJAMA pediatrics2014

Chorioamnionitis and early childhood outcomes among extremely low-gestational-age neonates.

Athina Pappas, Douglas E Kendrick, Seetha Shankaran, Barbara J Stoll, Edward F Bell, Abbott R Laptook, Michele C Walsh, Abhik Das, Ellen C Hale, Nancy S Newman and 2 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in JAMA pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 10 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 10 syntheses or guidelines pooled it, 275 citations in OpenAlex.

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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Athina PappasDepartment of Pediatrics, Wayne State University, Detroit, Michigan.
Douglas E KendrickSocial, Statistical, and Environmental Sciences Unit, RTI International, Research Triangle Park, North Carolina.
Seetha ShankaranDepartment of Pediatrics, Wayne State University, Detroit, Michigan.
Barbara J StollDepartment of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia.
Edward F BellDepartment of Pediatrics, University of Iowa, Iowa City.
Abbott R LaptookDepartment of Pediatrics, Women & Infants' Hospital, Brown University, Providence, Rhode Island.
Michele C WalshDepartment of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia.
Abhik DasSocial, Statistical, and Environmental Sciences Unit, RTI International, Rockville, Maryland.
Ellen C HaleDepartment of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia.
Nancy S NewmanDepartment of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, Ohio.
Rosemary D HigginsEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Children's Healthcare of Atlanta · USRTI International · USWayne State University · USCase Western Reserve University · USEmory University · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USUniversity of Iowa · USWomen & Infants Hospital of Rhode Island · US

Funding

Neonatal Research Network Data Coordinating Center (DCC)U10HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 2008 to 2017
$62.3M
YALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8M
UNIVERSITY OF ROCHESTER'S RESEARCH ASSOCIATE ORGANIZATIONUL1RR024160 · NCRR · UNIVERSITY OF ROCHESTER · PI PEARSON, THOMAS ARTHUR · 2006 to 2011
$38.7M
UNM HSC Clinical and Translational Science CenterUL1TR001449 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J, PANDHI, NANCY · 2015 to 2024
$36.9M
WORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUNDLEY, WILLIAM GREGORY · 1992 to 2010
$35.2M
XOLAIR IN SUBJECTS WITH MODERATE TO SEVERE ATOPIC DERMATITIS WITH FOOD ALLERGYM01RR000070 · NCRR · STANFORD UNIVERSITY · PI RASGON, NATALIE L · 1985 to 2008
$32.4M
ZUNI KIDNEY PROJECT STUDY I--POPULATION BASED SURVEY OF RENAL DISEASEM01RR000997 · NCRR · UNIVERSITY OF NEW MEXICO · PI ROLDAN, CARLOS A · 1985 to 2010
$30.0M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
ZOSUQUIDAR TRIHYDROCHLORIDE DURING CONVENTIONAL INDUCTION AND POST-REMISSIONM01RR000750 · NCRR · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI RODRIGUEZ, HENRY · 1985 to 2008
$25.5M
ZIPRASIDONE IN TOURETTES SYNDROME, OBSESSIVE COMPULSIVE &PERVASIVE DEV. DISORDERM01RR000125 · NCRR · YALE UNIVERSITY · PI ALPERN, ROBERT J · 1985 to 2006
$24.1M
Zosuquidar trihydrochloride for acute myeloid leukemia &refractory anemiaM01RR000080 · NCRR · UNIVERSITY HOSPITALS OF CLEVELAND · PI DAVIS, PAMELA B · 1985 to 2007
$22.2M
X LINKED NYSTAGMUS SYNDROME WITH FEATURES OF ALBINISMM01RR000039 · NCRR · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 1985 to 2007
$21.3M
NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1 TR001449NCRR NIH HHS M01 RR000039NCRR NIH HHS M01 RR000044NCRR NIH HHS M01 RR000054NCRR NIH HHS M01 RR000070NCRR NIH HHS M01 RR000080NCRR NIH HHS M01 RR000125NCRR NIH HHS M01 RR000633NCRR NIH HHS M01 RR000750NCRR NIH HHS M01 RR000997NCRR NIH HHS M01 RR007122NCRR NIH HHS M01 RR016587NCRR NIH HHS M01 RR125NCRR NIH HHS M01 RR16587NCRR NIH HHS M01 RR30NCRR NIH HHS M01 RR32NCRR NIH HHS M01 RR39NCRR NIH HHS M01 RR44NCRR NIH HHS M01 RR54NCRR NIH HHS M01 RR59NCRR NIH HHS M01 RR633NCRR NIH HHS M01 RR64NCRR NIH HHS M01 RR70NCRR NIH HHS M01 RR7122NCRR NIH HHS M01RR750NCRR NIH HHS M01 RR80NCRR NIH HHS M01 RR8084NCRR NIH HHS M01 RR997NCRR NIH HHS UL1 RR024139NCRR NIH HHS UL1 RR024160NCRR NIH HHS UL1 RR025764NCRR NIH HHS UL1 RR24139NCRR NIH HHS UL1 RR24160NCRR NIH HHS UL1 RR25764NICHD NIH HHS U10 HD021364NICHD NIH HHS U10 HD021373NICHD NIH HHS U10 HD021385NICHD NIH HHS U10 HD021397NICHD NIH HHS U10 HD027851NICHD NIH HHS U10 HD027853NICHD NIH HHS U10 HD027856NICHD NIH HHS U10 HD027871NICHD NIH HHS U10 HD027880NICHD NIH HHS U10 HD027904NICHD NIH HHS U10 HD034216NICHD NIH HHS U10 HD036790NICHD NIH HHS U10 HD040461NICHD NIH HHS U10 HD040492NICHD NIH HHS U10 HD040498NICHD NIH HHS U10 HD040521NICHD NIH HHS U10 HD040689NICHD NIH HHS U10 HD053089NICHD NIH HHS U10 HD053109NICHD NIH HHS U10 HD053119NICHD NIH HHS U10 HD053124NICHD NIH HHS U10 HD21364NICHD NIH HHS U10 HD21373NICHD NIH HHS U10 HD21385NICHD NIH HHS U10 HD21397NICHD NIH HHS U10 HD27851NICHD NIH HHS U10 HD27853NICHD NIH HHS U10 HD27856NICHD NIH HHS U10 HD27871NICHD NIH HHS U10 HD27880NICHD NIH HHS U10 HD27904NICHD NIH HHS U10HD34216NICHD NIH HHS U10HD36790NICHD NIH HHS U10 HD40461NICHD NIH HHS U10 HD40492NICHD NIH HHS U10 HD40498NICHD NIH HHS U10 HD40521NICHD NIH HHS U10 HD40689NICHD NIH HHS U10 HD53089NICHD NIH HHS U10 HD53119NICHD NIH HHS U10 HD53124NICHD NIH HHS UG1 HD027880NICHD NIH HHS UG1 HD034216NICHD NIH HHS UG1 HD053089NICHD NIH HHS UG1 HD053109NICHD NIH HHS UG1 HD068278NICHD NIH HHS UG1 HD087229
6 · The paper itself

Abstract

importanceChorioamnionitis is strongly linked to preterm birth and neonatal infection. The association between histological and clinical chorioamnionitis and cognitive, behavioral, and neurodevelopmental outcomes among extremely preterm neonates is less clear. We evaluated the impact of chorioamnionitis on 18- to 22-month neurodevelopmental outcomes in a contemporary cohort of extremely preterm neonates.

objectiveTo compare the neonatal and neurodevelopmental outcomes of 3 groups of extremely low-gestational-age infants with increasing exposure to perinatal inflammation: no chorioamnionitis, histological chorioamnionitis alone, or histological plus clinical chorioamnionitis. DESIGN, SETTING, AND

participantsLongitudinal observational study at 16 centers of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Two thousand three hundred ninety extremely preterm infants born at less than 27 weeks' gestational age (GA) between January 1, 2006, and December 31, 2008, with placental histopathology and 18 to 22 months' corrected age follow-up data were eligible. MAIN EXPOSURE: Chorioamnionitis. MAIN OUTCOMES AND MEASURES: Outcomes included cerebral palsy, gross motor functional limitation, behavioral scores (according to the Brief Infant-Toddler Social and Emotional Assessment), cognitive and language scores (according to the Bayley Scales of Infant and Toddler Development, Third Edition), and composite measures of death/neurodevelopmental impairment. Multivariable logistic and linear regression models were developed to assess the association between chorioamnionitis and outcomes while controlling for important variables known at birth.

resultsNeonates exposed to chorioamnionitis had a lower GA and higher rates of early-onset sepsis and severe periventricular-intraventricular hemorrhage as compared with unexposed neonates. In multivariable models evaluating death and neurodevelopmental outcomes, inclusion of GA in the model diminished the association between chorioamnionitis and adverse outcomes. Still, histological plus clinical chorioamnionitis was associated with increased risk of cognitive impairment as compared with no chorioamnionitis (adjusted odds ratio [OR], 2.38 [95% CI, 1.32 to 4.28] without GA; adjusted OR, 2.00 [95% CI, 1.10 to 3.64] with GA as a covariate). Histological chorioamnionitis alone was associated with lower odds of death/neurodevelopmental impairment as compared with histological plus clinical chorioamnionitis (adjusted OR, 0.68 [95% CI, 0.52 to 0.89] without GA; adjusted OR, 0.66 [95% CI, 0.49 to 0.89] with GA as a covariate). Risk of behavioral problems did not differ statistically between groups. CONCLUSIONS AND RELEVANCE: Antenatal exposure to chorioamnionitis is associated with altered odds of cognitive impairment and death/neurodevelopmental impairment in extremely preterm infants.

Indexed as

Infant, Extremely PrematureCerebral PalsyChild Behavior DisordersChorioamnionitisCognition DisordersDevelopmental DisabilitiesFemaleGestational AgeHumansInfantInfant, Premature, DiseasesLinear ModelsLogistic ModelsLongitudinal StudiesMalePregnancy

Identifiers

PMID24378638
PMCPMC4219500
OpenAlexW2069342143

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.