Evidence map›Paper›PMID 24378548›Full record

ArticleWorld journal of surgery2014

Quality of life after surgical treatment of early Barrett's cancer: a prospective comparison of the Ivor-Lewis resection versus the modified Merendino resection.

Ch Zapletal, Ch Heesen, J Origer, M Pauthner, O Pech, Ch Ell, Dietmar Lorenz

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in World journal of surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02855333 (The Merendino Procedure for Benign or Early Malignant Lesions of the Distal Esophagus/Gastroesophageal Junction is Feasible, Safe and Provides Good QoL), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02855333 completednot on this map

The Merendino Procedure for Benign or Early Malignant Lesions of the Distal Esophagus/Gastroesophageal Junction is Feasible, Safe and Provides Good QoL

TypeobservationalSponsorKantonsspital LiestalRan2014 to 2016Enrolled26ConditionsBenign or Early Malignant Lesion of the Distal Esophagus or Gastro-esophageal Junction Requiring Surgical ResectionArmsEORTC and QLQ-C30 / QLQ-OES24 questionnaire
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. [Updated German S3 guidelines on esophageal cancer and supplements from a surgical perspective].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2019
    Guideline
  3. Article
  4. Article
  5. Esophagogastric junction adenocarcinomas: individualization of resection with special considerations for Siewert type II, and Nishi types EG, E=G and GE cancers.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2020
    Review
  6. Article
  7. Quality of life after esophageal resection.Patient related outcome measures · 2018
    Article
  8. [Endoscopic and surgical treatment of early gastric and esophageal carcinoma].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2017
    Review
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ch ZapletalDepartment of Surgery, Dr. Horst-Schmidt-Klinik, Ludwig-Erhard-Str. 100, 65199, Wiesbaden, Germany, czap@gmx.net.
Ch Heesen
J Origer
M Pauthner
O Pech
Ch Ell
Dietmar Lorenz

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe Merendino (MER) procedure has been evaluated as an alternative to transthoracic esophageal resection (TER) for early stage Barrett's carcinoma. Apart from reducing morbidity and mortality, improvements concerning postoperative health-related quality of life (HRQL) have been postulated. The aim of our study was to compare HRQL between these procedures. MATERIALS AND

methodsBetween July 2000 and July 2007, 117 patients with early Barrett's carcinoma underwent surgery. Patients with tumor recurrence were excluded from the study. HRQL was assessed 1 and 2 years after surgery using the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (EORTC-QLQ-C30) and the QLQ-OES18 module. Patients recently diagnosed with early Barrett's carcinoma served as controls. Symptoms that showed a difference of more than ten between the control and the study groups were considered clinically relevant and were tested for significant differences between the study groups using the Mann-Whitney U test (p < 0.05).

resultsThe response rates for the questionnaires ranged between 70 and 93 %. In the MER group, more items reflected a clinical relevant impairment of HRQL than in the TER group. Significant complaints in the MER group included nausea/vomiting, appetite loss, local pain, difficulties with social eating, and choking. Moreover, we found a significant restriction concerning global health and emotional and social functioning in this group 1 year after surgery. 2 years postoperatively, hardly any differences between the operative techniques could be detected. The only symptom in favor of the MER procedure was a better dysphagia score postoperatively.

conclusionOur study suggests that MER procedure is not superior to subtotal esophagectomy with regard to HRQL.

Indexed as

Quality of LifeAgedBarrett EsophagusCohort StudiesDisease-Free SurvivalEarly DiagnosisEsophageal NeoplasmsEsophagectomyFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm Staging

Identifiers

PMID24378548

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.