ReviewFrontiers in oncology2013
Multi-layered cancer chromosomal instability phenotype.
Review in Frontiers in oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Profiling Numerical and Structural Chromosomal Instability in Different Cancer Types.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Distinct and Common Features of Numerical and Structural Chromosomal Instability across Different Cancer Types.Cancers · 2022Article
- Centrosome Aberrations as Drivers of Chromosomal Instability in Breast Cancer.Endocrinology · 2021Review
- Genome instability in multiple myeloma.Leukemia · 2020Review
- Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2019Article
- Integrative Profiling of Alternative Splicing Induced byMolecules and cells · 2018Article
- Dynamics of CRISPR/Cas9-mediated genomic editing of theOncology letters · 2018Article
- Expression-based analyses indicate a central role for hypoxia in driving tumor plasticity through microenvironment remodeling and chromosomal instability.NPJ systems biology and applications · 2018Article
- A One-Step PCR-Based Assay to Evaluate the Efficiency and Precision of Genomic DNA-Editing Tools.Molecular therapy. Methods & clinical development · 2017Article
- Chromosomal Instability as a Driver of Tumor Heterogeneity and Evolution.Cold Spring Harbor perspectives in medicine · 2017Review
- DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer.Nature communications · 2017Article
- Biomarkers of genome instability and cancer epigenetics.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Article
- Functional annotation of noncoding variants and prioritization of cancer-associated lncRNAs in lung cancer.Oncology letters · 2016Article
- Re-replication of a centromere induces chromosomal instability and aneuploidy.PLoS genetics · 2015Article
- Molecular pathways: regulation and targeting of kinetochore-microtubule attachment in cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Article
- Aneuploidy and chromosomal instability in cancer: a jackpot to chaos.Cell division · 2015Article
- Chromosomal instability selects gene copy-number variants encoding core regulators of proliferation in ER+ breast cancer.Cancer research · 2014Article
- Chromosomal instability, aneuploidy, and cancer.Frontiers in oncology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Whole-chromosomal instability (W-CIN) - unequal chromosome distribution during cell division - is a characteristic feature of a majority of cancer cells distinguishing them from their normal counterparts. The precise molecular mechanisms that may cause mis-segregation of chromosomes in tumor cells just recently became more evident. The consequences of W-CIN are numerous and play a critical role in carcinogenesis. W-CIN mediates evolution of cancer cell population under selective pressure and can facilitate the accumulation of genetic changes that promote malignancy. It has both tumor-promoting and tumor-suppressive effects, and their balance could be beneficial or detrimental for carcinogenesis. The characterization of W-CIN as a complex multi-layered adaptive phenotype highlights the intra- and extracellular adaptations to the consequences of genome reshuffling. It also provides a framework for targeting aggressive chromosomally unstable cancers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.