SynthesisPloS one2013
CYP2D6*4 allele polymorphism increases the risk of Parkinson's disease: evidence from meta-analysis.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Association Between IL-4 Polymorphisms and Risk of Liver Disease: An Updated Meta-Analysis.Medicine · 2015Pooled it
- Associations between SelectedMedicina (Kaunas, Lithuania) · 2023Article
- CYP2D6 and CYP2C19 Genes Associated with Tricontinental and Latin American Ancestry of Pe-ruviansDrug metabolism and bioanalysis letters · 2023Article
- Human CYP2D6 in the Brain Is Protective Against Harmine-Induced Neurotoxicity: Evidence from Humanized CYP2D6 Transgenic Mice.Molecular neurobiology · 2020Article
- Human CYP2D6 Is Functional in Brain In Vivo: Evidence from Humanized CYP2D6 Transgenic Mice.Molecular neurobiology · 2020Article
- Cytochrome P450 2D6 and Parkinson's Disease: Polymorphism, Metabolic Role, Risk and Protection.Neurochemical research · 2017Review
- Further evidence for the association of CYP2D6*4 gene polymorphism with Parkinson's disease: a case control study.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2017Article
- Role of CYP2E1 polymorphisms in breast cancer: a systematic review and meta-analysis.Cancer cell international · 2017Article
- Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration.Frontiers in neuroscience · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany epidemiological studies have been conducted to explore the association between a single CYP2D6 gene polymorphism and Parkinson's disease (PD) susceptibility. However, the results remain controversial.
objectivesTo clarify the effects of a single CYP2D6 gene polymorphism on the risk of PD, a meta-analysis of all available studies relating to CYP2D6*4 polymorphism and the risk of PD was conducted.
methodsA comprehensive literature search of PubMed, EMBASE, and the China National Knowledge Infrastructure (CNKI) up to September 1, 2013 was conducted. Data were extracted by two independent authors and pooled odds ratio (OR) with 95% confidence interval (CI) were calculated. Meta-regression, Galbraith plots, subgroup analysis, sensitivity analysis, and publication bias analysis were also performed.
resultsTwenty-two separate comparisons consisting of 2,629 patients and 3,601 controls were included in our meta-analysis. The pooled analyses showed a significant association between CYP2D6*4G/A polymorphism and PD risk in all of the comparisons (A vs. G allele: OR = 1.28, 95% CI = 1.14-1.43, P = 0.001; AA vs. GG: OR = 1.43, 95% CI = 1.06-1.93, P = 0.018; AG vs. GG: OR = 1.22, 95% CI = 1.06-1.40, P = 0.006; AG+AA vs. GG: OR = 1.26, 95% CI = 1.10-1.44, P = 0.001; AA vs. AG+GG: OR = 1.37, 95% CI = 1.02-1.83, P = 0.036). In subgroup analysis stratified by ethnicity, significant associations were also demonstrated in Caucasians but not in Asians. No significant association was found in subgroup analysis stratified by age of onset or disease form.
conclusionsWe concluded that the CYP2D6*4G/A polymorphism denotes an increased genetic susceptibility to PD in the overall population, especially in Caucasians. Further large and well-designed studies are needed to confirm this association.
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