ArticlePloS one2013
Estimation of the underlying burden of pertussis in adolescents and adults in Southern Ontario, Canada.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Whooping cough hospitalisations among patients with chronic conditions: a retrospective analysis of incidence and costs, France, 2008 to 2020.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026Article
- Test-adjusted estimation for pertussis incidence in greater Toronto, Canada, 1993-2006.BMC infectious diseases · 2025Article
- Country-Specific Data and Priorities for Pertussis in Latin America: Recent Findings From the Global Pertussis Initiative.Open forum infectious diseases · 2025Review
- Validating pertussis data measures using electronic medical record data in Ontario, Canada 1986-2016.Vaccine: X · 2023Article
- Improving estimates of pertussis burden in Ontario, Canada 2010-2017 by combining validation and capture-recapture methodologies.PloS one · 2023Article
- ReducedFrontiers in aging · 2021Article
- Immunological and Clinical Benefits of Maternal Immunization Against Pertussis: A Systematic Review.Infectious diseases and therapy · 2019Review
- Is adding maternal vaccination to prevent whooping cough cost-effective in Australia?Human vaccines & immunotherapeutics · 2018Article
- Under-reporting of pertussis in Ontario: A Canadian Immunization Research Network (CIRN) study using capture-recapture.PloS one · 2018Article
- Pertussis: Microbiology, Disease, Treatment, and Prevention.Clinical microbiology reviews · 2016Review
- Pertussis immunity and epidemiology: mode and duration of vaccine-induced immunity.Parasitology · 2016Article
- What to do about pertussis vaccines? Linking what we know about pertussis vaccine effectiveness, immunology and disease transmission to create a better vaccine.Pathogens and disease · 2015Review
- Validating the Use of Google Trends to Enhance Pertussis Surveillance in California.PLoS currents · 2015Article
- Understanding Trends in Pertussis Incidence: An Agent-Based Model Approach.American journal of public health · 2015Article
- Examining the role of different age groups, and of vaccination during the 2012 Minnesota pertussis outbreak.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite highly successful vaccination programs and high vaccine uptake, both endemic pertussis and periodic pertussis outbreaks continue to occur. The under-recognized role of adolescents and adults in disease transmission, due to waning immunity following natural infection and vaccination, and reduced likelihood of correct diagnosis, may contribute to pertussis persistence. We constructed a mathematical model to describe the transmission of pertussis in Southern Ontario in both pre-vaccine and vaccine eras, to estimate the underlying burden of pertussis in the population. The model was well calibrated using the best available data on pertussis in the pre-vaccination (1880-1929) and vaccination (1993-2004) eras in Ontario. Pertussis under-reporting by age group was estimated by comparing model-projected incidence to reported laboratory-confirmed cases for Greater Toronto. Best-fit model estimates gave a basic reproductive number of approximately 10.6, (seasonal range 9.9 to 11.5). Under-reporting increased with age, and approximately >95% of infections in children were caused by infections in persons with waning immunity to pertussis following prior infection or vaccination. A well-calibrated model suggests that under-recognized cases of pertussis in older individuals are likely to be an important driver of ongoing pertussis outbreaks in children. Model projections strongly support enhancement of booster vaccination efforts in adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.