ArticlePloS one2013
Determinants of progression to AIDS and death following HIV diagnosis: a retrospective cohort study in Wuhan, China.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
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- Prevalence and Factors Influencing Antiretroviral Therapy (ART) Nonadherence in Men During Different Stages of the Life Course: A Case Study in Greater Gaborone, Botswana.AIDS research and treatment · 2025Article
- Effect of Late Testing and Antiretroviral Treatment on Mortality Among People Living With HIV in the Era of Treat-All in Guangdong Province, China, 1992-2018: A Cohort Study.Frontiers in public health · 2022Article
- Molecular Biology and Diversification of Human Retroviruses.Frontiers in virology (Lausanne, Switzerland) · 2022Article
- Critical appraisal and external validation of a prognostic model for survival of people living with HIV/AIDS who underwent antiretroviral therapy.Diagnostic and prognostic research · 2020Article
- Modelling HIV disease process and progression in seroconversion among South Africa women: using transition-specific parametric multi-state model.Theoretical biology & medical modelling · 2020Article
- Multilevel ordinal model for CD4 count trends in seroconversion among South Africa women.BMC infectious diseases · 2020Article
- Sex differences in HIV treatment outcomes and adherence by exposure groups among adults in Guangdong, China: A retrospective observational cohort study.EClinicalMedicine · 2020Article
- Modelling immune deterioration, immune recovery and state-specific duration of HIV-infected women with viral load adjustment: using parametric multistate model.BMC public health · 2020Article
- Factors associated with 36-month loss to follow-up and mortality outcomes among HIV-infected adults on antiretroviral therapy in Central Kenya.BMC public health · 2020Article
- Associated factors for progression to AIDS among HIV-infected people who use drugs: a retrospective cohort study in Dongguan, China.BMJ open · 2019Article
- Overrepresentation of Injection Drug Use Route of Infection Among Human Immunodeficiency Virus Long-term Nonprogressors: A Nationwide, Retrospective Cohort Study in China, 1989-2016.Open forum infectious diseases · 2019Article
- [Survival analysis in people diagnosed with HIV/AIDS in Puerto Rico].Revista Puertorriquena de medicina y salud publica · 2018Article
- Trends in the incidence of AIDS and epidemiological features in Tianjin, China from 2005 to 2016.Oncotarget · 2017Article
- HIV Infection in the Elderly: Arising Challenges.Journal of aging research · 2016Review
- Late HIV Diagnosis: Proposed Common Definitions and Associations With Short-Term Mortality.Medicine · 2015Observational
- Mortality, Causes of Death and Associated Factors Relate to a Large HIV Population-Based Cohort.PloS one · 2015Observational
- Rates and risk factors associated with the progression of HIV to AIDS among HIV patients from Zhejiang, China between 2008 and 2012.AIDS research and therapy · 2015Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo identify determinants associated with disease progression and death following human immunodeficiency virus (HIV) diagnosis.
methodsDisease progression data from the diagnosis of HIV infection or acquiring immunodeficiency syndrome (AIDS) to February 29, 2012 were retrospectively collected from the national surveillance system databases and the national treatment database in Wuhan, China. Kaplan-Meier method, Logistic regression and Cox proportional hazards model were applied to identify the related factors of progression to AIDS or death following HIV diagnosis.
resultsBy the end of February 2012, 181 of 691 HIV infectors developed to AIDS, and 129 of 470 AIDS patients died among whom 289 cases received concurrent HIV/AIDS diagnosis. Compared with men infected through homosexual behavior, injection drug users possessed sharply decreased hazard ratio (HR) for progression to AIDS following HIV diagnosis [HR = 0.31, 95% confidence interval (CI), 0.18-0.54, P = 4.01×10(-5)]. HIV infectors at least 60 years presented 1.15-fold (HR = 2.15, 95% CI, 1.15-4.03, P = 0.017) increased risk to develop AIDS when compared with those aged 17-29 years. Similarly, AIDS patients with diagnosis ages between 50 and 59 years were at a 1.60-fold higher risk of death (HR = 2.60, 95% CI, 1.18-5.72, P = 0.017) compared to those aged 19-29 years. AIDS patients with more CD4(+) T-cells within 6 months at diagnosis (cell/µL) presented lower risk of death (HR = 0.29 for 50- vs <50, 95% CI, 0.15-0.59, P = 0.001). The highly active antiretroviral therapy (HAART) delayed progression to AIDS from HIV diagnosis (HR = 0.15, 95% CI, 0.07-0.34, P = 6.46×10(-6)) and reduced the risk of death after AIDS diagnosis (HR = 0.02, 95% CI, 0.01-0.04, P = 7.25×10(-25)).
conclusionsProgression to AIDS and death following HIV diagnosis differed in age at diagnosis, transmission categories, CD4(+) T-cell counts and HAART. Effective interventions should target those at higher risk for morbidity or mortality, ensuring early diagnosis and timely treatment to slow down the disease progression.
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