ArticlePloS one2013
Clinical forms of canine visceral Leishmaniasis in naturally Leishmania infantum-infected dogs and related myelogram and hemogram changes.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 68 citations in OpenAlex.
- The Involvement of the Omentum in Defensive Peritoneal Mechanisms: New Evidence from Dogs Naturally Infected withAnimals : an open access journal from MDPI · 2026Article
- Hematological Ratios inAnimals : an open access journal from MDPI · 2026Article
- Hematological and Biochemical Outcomes of Leishmania Infantum Infection in the South American Coati (Nasua nasua) in an Endemic Area of Visceral Leishmaniasis in Central Western Brazil.Acta parasitologica · 2026Article
- Emergence of autochthonousFrontiers in veterinary science · 2025Article
- Article
- Clinical anemia predicts dermal parasitism and reservoir infectiousness during progressive visceral leishmaniosis.PLoS neglected tropical diseases · 2024Article
- Clinical significance of blood cell ratios in healthy and sick Leishmania infantum-seropositive dogs.Parasites & vectors · 2024Article
- Distribution of and Relationships between Epidemiological and Clinicopathological Parameters in Canine Leishmaniosis: A Retrospective Study of 15 Years (2009-2023).Pathogens (Basel, Switzerland) · 2024Article
- Signalment, Immunological and Parasitological Status and Clinicopathological Findings ofAnimals : an open access journal from MDPI · 2023Article
- Characterization and Proteomic Analysis of Plasma EVs Recovered from Healthy and Diseased Dogs with Canine Leishmaniosis.International journal of molecular sciences · 2023Article
- Clinical, hematological, biochemical, and histopathological evaluations in domestic cats (Felis catus) infected by Leishmania infantum.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2023Article
- Elucidating the role played by bone marrow in visceral leishmaniasis.Frontiers in cellular and infection microbiology · 2023Review
- Hemogram Findings in Cats from an Area Endemic forVeterinary sciences · 2022Article
- Humoral and Cellular Immune Response in Asymptomatic Dogs with Visceral Leishmaniasis: A Review.Vaccines · 2022Review
- Canine Leishmaniasis in an Endemic Area for Human Leishmaniasis in Nicaragua.Journal of tropical medicine · 2022Article
- Increased levels of cortisol are associated with the severity of experimental visceral leishmaniasis in a Leishmania (L.) infantum-hamster model.PLoS neglected tropical diseases · 2021Article
- Hematological Changes in Dogs with Visceral Leishmaniasis Are Associated with Increased IFN-γ and TNF Gene Expression Levels in the Bone Marrow.Microorganisms · 2021Article
- FML/QuilA-Vaccinated Dogs Naturally Infected withBioMed research international · 2021Article
- Modulation of Host Immune Response duringFrontiers in immunology · 2021Article
- Prognostic Factors and Life Expectancy in Canine Leishmaniosis.Veterinary sciences · 2020Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hematological analysis has limited applications for disease diagnosis in Leishmania infantum-infected dogs, but it can be very important in evaluating the clinical forms of the disease and in understanding the evolution of canine visceral leishmaniasis (CVL) pathogenesis. Recently, we demonstrated that alterations in leucopoiesis and erythropoiesis are related to clinical status and bone marrow parasite density in dogs naturally infected by L. infantum. To further characterize these alterations, we evaluated the association between the hematological parameters in bone marrow and peripheral blood alterations in groups of L. infantum-infected dogs: asymptomatic I (AD-I: serum negative/PCR+), asymptomatic II (AD-II: serum positive), oligosymptomatic (OD), and symptomatic (SD). Results were compared with those from noninfected dogs (NID). The SD group was found to present a decrease in erythropoietic lineage with concomitant reductions in erythrocytes, hemoglobin, and hematocrit parameters, resulting in anemia. The SD group also had increased neutrophils and precursors and decreased band eosinophils and eosinophils, leading to peripheral blood leucopenia. In the AD-II group, lymphocytosis occurred in both the peripheral blood and the bone marrow compartments. The SD group exhibited lymphocytosis in the bone marrow, with lymphopenia in the peripheral blood. In contrast, the AD-I group, showed no significant changes suggestive of CVL, presenting normal counts in bone marrow and peripheral blood. Our results showed for the first time that important changes in hematopoiesis and hematological parameters occur during ongoing CVL in naturally infected dogs, mainly in symptomatic disease. Taken together, our results based on myelogram and hemogram parameters enable better understanding of the pathogenesis of the anemia, lymphocytosis, and lymphopenia, as well as the leucopenia (eosinopenia and monocytopenia), that contribute to CVL prognosis.
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