ArticlePloS one2013
Long-term effects of subacute ruminal acidosis (SARA) on milk quality and hepatic gene expression in lactating goats fed a high-concentrate diet.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 92 citations in OpenAlex.
- Feeding a high-grain diet reduces the percentage of LPS clearance and enhances immune gene expression in goat liver.BMC veterinary research · 2015Trial
- Microbial and Metabolic Dysbiosis in Ruminal Acidosis: Mechanisms, Host Responses, and Microbiota-Targeted Mitigation Strategies.Microorganisms · 2026Review
- Sodium Bicarbonate Can Increase Milk Fat Concentration in Lactating Ewes Fed Ryegrass Herbage Rich in Water-Soluble Carbohydrates.Animals : an open access journal from MDPI · 2026Article
- Host-microbiome interplay supports heat stress resilience in zebu calves.Animal microbiome · 2026Article
- Article
- Influence of Dietary Forage Neutral Detergent Fiber on Ruminal Fermentation, Chewing Activity, Nutrient Digestion, and Ruminal Microbiota of Hu Sheep.Animals : an open access journal from MDPI · 2025Article
- In vitro and in vivo analysis of rumen fermentation after supplementary niacin in high concentrated fed cattle.Tropical animal health and production · 2024Article
- Metabolomics Reveals the Mechanism by Which Sodium Butyrate Promotes the Liver Pentose Phosphate Pathway and Fatty Acid Synthesis in Lactating Goats.Animals : an open access journal from MDPI · 2024Article
- The Expression of Selected Cytokine Genes in the Livers of Young Castrated Bucks after Supplementation with a Mixture of DryAnimals : an open access journal from MDPI · 2023Article
- Effect of Supplementation withGenes · 2023Article
- Genome wide transcriptome analysis provides bases on hepatic lipid metabolism disorder affected by increased dietary grain ratio in fattening lambs.BMC genomics · 2023Article
- Effects of a High-Concentrate Diet on the Blood Parameters and Liver Transcriptome of Goats.Animals : an open access journal from MDPI · 2023Article
- Population shifts in some faeces and rumen bacteria profiles and subsequent blood LPS and lactate concentrations in lambs in the early period of subacute ruminal acidosis.Veterinary medicine and science · 2023Article
- Ameliorative effects of supranutritional selenium on TLR-4-NF-kB-TNF-α-mediated hepatic oxidative injury and inflammation in goats fed high concentrate diet.Food science & nutrition · 2022Article
- Niacin mitigates rumen epithelial damage in vivo by inhibiting rumen epithelial cell apoptosis on a high concentrate diet.Veterinary research communications · 2022Article
- Elevated thyroid hormones caused by high concentrate diets participate in hepatic metabolic disorders in dairy cows.Animal bioscience · 2022Article
- The Role of Rumen Microbiota and Its Metabolites in Subacute Ruminal Acidosis (SARA)-Induced Inflammatory Diseases of Ruminants.Microorganisms · 2022Review
- The Rumen Microbiota Contributes to the Development of Mastitis in Dairy Cows.Microbiology spectrum · 2022Article
- Direct effect of lipopolysaccharide and histamine on permeability of the rumen epithelium of steers ex vivo.Journal of animal science · 2022Article
- Weighted Gene Co-expression Network Analysis Identifies Specific Modules and Hub Genes Related to Subacute Ruminal Acidosis.Frontiers in veterinary science · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe mechanism underlying the decline in milk quality during periods of feeding high-concentrate diets to dairy ruminants is not well documented. The aim of this study was to investigate the metabolic changes in the liver that contribute to the input of substrate precursors to the mammary gland after feeding a high-concentrate diet to lactating goats for a long period. EXPERIMENTAL
designEight mid-lactating goats with rumen cannulas were randomly assigned to two groups. For 9 weeks, the treatment group was fed a high-concentrate diet (60% concentrate of dry matter, HC) and the control group was fed a low-concentrate diet (40% concentrate of dry matter, LC). Ruminal fluid, plasma, and liver tissues were sampled, microarray techniques and real-time polymerase chain reaction were used to evaluate metabolic parameters and gene expression in liver.
resultsFeeding a 60%-concentrate diet for 9 weeks resulted in a significant decrease in rumen pH. Changes in fat and protein content also occurred, which negatively affected milk quality. Plasma levels of leptin (p = 0.058), non-esterified fatty acid (p = 0.071), and glucose (p = 0.014) increased markedly in HC group. Plasma cortisol concentration was significantly elevated in the treatment group (p<0.05). Expression of the glucocorticoid receptor protein gene was significantly down-regulated (p<0.05) in the liver. The expression of genes for interleukin 1β, serum amyloid A, C-reactive protein, and haptoglobin mRNA was significantly increased (p<0.05) in the HC group. GeneRelNet analysis showed that gene expression involved in inflammatory responses and the metabolism of lipids, protein, and carbohydrate were significantly altered by feeding a high-concentrate diet for 9 weeks.
conclusionsActivation of the acute phase response and the inflammatory response may contribute to nutrient partitioning and re-distribution of energy in the liver, and ultimately lead to a decline in milk quality.
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