Evidence map›Paper›PMID 24376545›Full record

ArticlePloS one2013

Hemodynamic and neuropathological analysis in rats with aluminum trichloride-induced Alzheimer's disease.

Szu-Ming Chen, Chi-Chen Fan, Ming-Shiuan Chiue, Chi Chou, Jyh-Horng Chen, Ruey-Shyang Hseu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Szu-Ming ChenDepartment of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei, Taiwan ; Department of Medical Laboratory Science and Biotechnology, Yuanpei University, Hsinchu, Taiwan.
Chi-Chen FanDepartment of Medical Laboratory Science and Biotechnology, Yuanpei University, Hsinchu, Taiwan ; Department of Physiology, Mackay Memorial Hospital, Taipei, Taiwan.
Ming-Shiuan ChiueInterdisciplinary MRI/MRS Lab, Department of Electrical Engineering and Molecular Imaging Center, National Taiwan University, Taipei, Taiwan ; Graduate Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan.
Chi ChouDepartment of Physiology, Mackay Memorial Hospital, Taipei, Taiwan.
Jyh-Horng ChenInterdisciplinary MRI/MRS Lab, Department of Electrical Engineering and Molecular Imaging Center, National Taiwan University, Taipei, Taiwan.
Ruey-Shyang HseuDepartment of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei, Taiwan.
National Taiwan University · TWMackay Memorial Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsHemodynamic normality is crucial to maintaining the integrity of cerebral vessels and, therefore, preserving the cognitive functions of Alzheimer's disease patients. This study investigates the implications of the hemodynamic changes and the neuropathological diversifications of AlCl3-induced AD.

methodsThe experimental animals were 8- to 12-wk-old male Wistar rats. The rats were randomly divided into 2 groups: a control group and a (+)control group. Food intake, water intake, and weight changes were recorded daily for 22 wk. Synchronously, the regional cerebral blood flow (rCBF) of the rats with AlCl3-induced AD were measured using magnetic resonance imaging (MRI). The hemorheological parameters were analyzed using a computerized auto-rotational rheometer. The brain tissue of the subjects was analyzed using immunohistological chemical (IHC) staining to determine the beta-amyloid (Aβ) levels.

resultsThe results of hemodynamic analysis revealed that the whole blood viscosity (WBV), fibrinogen, plasma viscosity and RBC aggregation index (RAI) in (+)control were significantly higher than that of control group, while erythrocyte electrophoresis (EI) of whole blood in (+)control were significantly lower than that of control group. The results of acetylcholinesterase-RBC (AChE-RBC)in the (+)control group was significantly higher than that of the control group. The results also show that the reduction of rCBF in rats with AlCl3-induced AD was approximately 50% to 60% that of normal rats. IHC stain results show that significantly more Aβ plaques accumulated in the hippocampus and cortex of the (+)control than in the control group.

conclusionThe results accentuate the importance of hemorheology and reinforce the specific association between hemodynamic and neuropathological changes in rats with AlCl3-induced AD. Hemorheological parameters, such as WBV and fibrinogen, and AChE-RBC were ultimately proven to be useful biomarkers of the severity and progression of AD patients. In addition, the parameters can be substituted for invasive inspection in therapeutic intervention.

Indexed as

HemodynamicsAluminum ChlorideAluminum CompoundsAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBlood ViscosityBrainCatalaseCerebral CortexCerebrovascular CirculationChloridesEnvironmentEscape ReactionGlutathione PeroxidaseHippocampusAluminum ChlorideAluminum CompoundsAmyloid beta-PeptidesCatalaseChloridesGlutathione PeroxidaseSuperoxide Dismutase

Identifiers

PMID24376545
PMCPMC3869709
OpenAlexW2017992896

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.