ArticlePloS one2013
The 1H NMR profile of healthy dog cerebrospinal fluid.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Computed Tomography and Fluorescence Spectroscopy Blood Plasma Analysis Study for Kynurenic Acid as a Diagnostic Approach to Chronic Coenurosis in Sheep.Life (Basel, Switzerland) · 2024Article
- NMR-based metabolomic investigation of dogs with acute flaccid paralysis due to tick paralysis.Veterinary medicine and science · 2024Article
- Integrating (Nutri-)Metabolomics into the One Health Tendency-The Key for Personalized Medicine Advancement.Metabolites · 2023Review
- A Real-Life Reproducibility Assessment for NMR Metabolomics.Diagnostics (Basel, Switzerland) · 2022Article
- Monitoring Methylmalonic Aciduria by NMR Urinomics.Molecules (Basel, Switzerland) · 2020Article
- Canine metabolomics advances.Metabolomics : Official journal of the Metabolomic Society · 2020Review
- Citrate, a Ubiquitous Key Metabolite with Regulatory Function in the CNS.Neurochemical research · 2017Review
- Age-Related 1H NMR Characterization of Cerebrospinal Fluid in Newborn and Young Healthy Piglets.PloS one · 2016Article
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4 authors.
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Abstract
The availability of data for reference values in cerebrospinal fluid for healthy humans is limited due to obvious practical and ethical issues. The variability of reported values for metabolites in human cerebrospinal fluid is quite large. Dogs present great similarities with humans, including in cases of central nervous system pathologies. The paper presents the first study on healthy dog cerebrospinal fluid metabolomic profile using (1)H NMR spectroscopy. A number of 13 metabolites have been identified and quantified from cerebrospinal fluid collected from a group of 10 mix breed healthy dogs. The biological variability as resulting from the relative standard deviation of the physiological concentrations of the identified metabolites had a mean of 18.20% (range between 9.3% and 44.8%). The reported concentrations for metabolites may be used as normal reference values. The homogeneity of the obtained results and the low biologic variability show that the (1)H NMR analysis of the dog's cerebrospinal fluid is reliable in designing and interpreting clinical and therapeutic trials in dogs with central nervous system pathologies.
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