ArticlePloS one2013
Stabilization of Arabidopsis DREB2A is required but not sufficient for the induction of target genes under conditions of stress.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 66 citations in OpenAlex.
- TheInternational journal of molecular sciences · 2026Article
- The feedback regulation between DREB2C and E3 ligases DEL1/DEL2 for balancing the initial growth and ABA signaling in Arabidopsis.The New phytologist · 2026Article
- Expression profiles of transcription factors and aquaporins suggest putative roles in rubber biosynthesis regulation and drought stress adaptation in guayule.Scientific reports · 2026Article
- Integrating multiomic resources and gene expression studies to identify candidates for engineering climate-resilientFrontiers in plant science · 2026Review
- The Salt Tolerance-Related Protein (STRP) Is a Positive Regulator of the Response to Salt Stress inPlants (Basel, Switzerland) · 2023Article
- Article
- Molecular mechanisms of plant tolerance to heat stress: current landscape and future perspectives.Plant cell reports · 2021Review
- ZmbHLH124 identified in maize recombinant inbred lines contributes to drought tolerance in crops.Plant biotechnology journal · 2021Article
- Control of ABA Signaling and Crosstalk with Other Hormones by the Selective Degradation of Pathway Components.International journal of molecular sciences · 2021Review
- Advances in Wheat Physiology in Response to Drought and the Role of Plant Growth Promoting Rhizobacteria to Trigger Drought Tolerance.Microorganisms · 2021Review
- The Ubiquitin Switch in Plant Stress Response.Plants (Basel, Switzerland) · 2021Review
- CUL3 E3 ligases in plant development and environmental response.Nature plants · 2021Review
- Intrinsic Disorder in Plant Transcription Factor Systems: Functional Implications.International journal of molecular sciences · 2020Review
- Mediator Complex: A Pivotal Regulator of ABA Signaling Pathway and Abiotic Stress Response in Plants.International journal of molecular sciences · 2020Review
- SUMOylation Stabilizes the Transcription Factor DREB2A to Improve Plant Thermotolerance.Plant physiology · 2020Article
- The protein turnover of Arabidopsis BPM1 is involved in regulation of flowering time and abiotic stress response.Plant molecular biology · 2020Article
- NF-YB2 and NF-YB3 Have Functionally Diverged and Differentially Induce Drought and Heat Stress-Specific Genes.Plant physiology · 2019Article
- Heat-induced inhibition of phosphorylation of the stress-protective transcription factor DREB2A promotes thermotolerance ofThe Journal of biological chemistry · 2019Article
- Co-expression network analysis and cis-regulatory element enrichment determine putative functions and regulatory mechanisms of grapevine ATL E3 ubiquitin ligases.Scientific reports · 2018Article
- Roles of E3 Ubiquitin-Ligases in Nuclear Protein Homeostasis during Plant Stress Responses.Frontiers in plant science · 2018Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Arabidopsis thaliana transcription factor DEHYDRATION-RESPONSIVE ELEMENT-BINDING PROTEIN2A (DREB2A) controls the expression of many genes involved in the plant's response to dehydration and heat stress. Despite the significance of post-translational regulation in DREB2A activation, the mechanism underlying this activation remains unclear. Here, with the aid of a newly produced antibody against DREB2A, we characterized the regulation of DREB2A stability in plants exposed to stress stimuli. Endogenous DREB2A accumulated in wild-type Arabidopsis plants subjected to dehydration and heat stress. A degradation assay using Arabidopsis T87 suspension-cultured cells revealed that DREB2A protein degradation was inhibited at high temperatures. The proteasome-dependent degradation of DREB2A required the import of this protein into the nucleus. The E3 ligases DRIP1 and DRIP2 were involved in this process under both normal and stressful conditions; however, other E3 ligases may have also been involved, at least during the late stages of the heat stress response. Although the constitutive expression of DREB2A resulted in an overproduction of DREB2A and enhanced target gene induction during stress in transgenic plants, the accumulation of DREB2A caused by proteasome inhibitors did not induce target gene expression. Thus, the stabilization of DREB2A is important but not sufficient to induce target gene expression; further activation processes are required.
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