ArticleFrontiers in biology2013
The anatomy, function, and development of mammalian Aβ low-threshold mechanoreceptors.
Article in Frontiers in biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The interplay between epidermal cells and the cutaneous sensory nervous: a systematic review.Frontiers in immunology · 2026Pooled it
- The effects of Vibro-medical insole on vibrotactile sensation in diabetic patients with mild-to-moderate peripheral neuropathy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Trial
- Exercise Guidelines for Enhancing Mobility and Stability in Individuals with Severe Obesity.Journal of obesity & metabolic syndrome · 2026Review
- From the TPR pathway and the neuroimmune unit to the cutaneous HPA axis: a neuro-endo-immune cross-talk in rosacea.Frontiers in medicine · 2026Review
- ROCK inhibition promotes axon and myelin regeneration via PI3K/Akt/GSK3β in a mouse sciatic nerve injury model.International journal of molecular medicine · 2026Article
- Active touch in tactile perceptual discrimination: brain activity and behavioral responses to surface differences.Experimental brain research · 2025Article
- Characterization of human iPSC-derived sensory neurons and their functional assessment using multi electrode array.Scientific reports · 2024Article
- Review
- A role for axon-glial interactions and Netrin-G1 signaling in the formation of low-threshold mechanoreceptor end organs.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The spatial profile of skin indentation shapes tactile perception across stimulus frequencies.Scientific reports · 2022Article
- Article
- Nerve regrowth can be painful.Nature · 2022Article
- The Trinity of Skin: Skin Homeostasis as a Neuro-Endocrine-Immune Organ.Life (Basel, Switzerland) · 2022Review
- Sensory innervation of the human male prepuce: Meissner's corpuscles predominate.Journal of anatomy · 2021Article
- A common computational principle for vibrotactile pitch perception in mouse and human.Nature communications · 2021Article
- The mechanosensory neurons of touch and their mechanisms of activation.Nature reviews. Neuroscience · 2021Review
- Vibration Perception Thresholds of Skin Mechanoreceptors Are Influenced by Different Contact Forces.Journal of clinical medicine · 2021Article
- Glans clitoris innervation: PIEZO2 and sexual mechanosensitivity.Journal of anatomy · 2021Article
- The Human Cutaneous Sensory Corpuscles: An Update.Journal of clinical medicine · 2021Review
- Verification and characterisation of human digital Ruffini's sensory corpuscles.Journal of anatomy · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Touch sensation is critical for our social and environmental interactions. In mammals, most discriminative light touch sensation is mediated by the Aβ low-threshold mechanoreceptors. Cell bodies of Aβ low-threshold mechanoreceptors are located in the dorsal root ganglia and trigeminal ganglia, which extend a central projection innervating the spinal cord and brain stem and a peripheral projection innervating the specialized mechanosensory end organs. These specialized mechanosensory end organs include Meissner's corpuscles, Pacinian corpuscles, lanceolate endings, Merkel cells, and Ruffini corpuscles. The morphologies and physiological properties of these mechanosensory end organs and their innervating neurons have been investigated for over a century. In addition, recent advances in mouse genetics have enabled the identification of molecular mechanisms underlying the development of Aβ low-threshold mechanoreceptors, which highlight the crucial roles of neurotrophic factor signaling and transcription factor activity in this process. Here, we will review the anatomy, physiological properties, and development of mammalian low-threshold Aβ mechanoreceptors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.