ReviewFrontiers in physiology2013
Structure of giant muscle proteins.
Review in Frontiers in physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Obscurin deficiency leads to compensated dilated cardiomyopathy and increased arrhythmias.The Journal of general physiology · 2025Article
- The varied functions of the giant muscle scaffold protein obscurin.Frontiers in cell and developmental biology · 2025Review
- Proteomic and metabolomic profiling of aged pork loin chops reveals molecular phenotypes linked to pork tenderness.Journal of animal science · 2024Article
- Distinct myofibrillar sub-proteomic profiles are associated with the instrumental texture of aged pork loin.Journal of animal science · 2023Article
- Characterizing the sarcoplasmic proteome of aged pork chops classified by purge loss.Journal of animal science · 2023Article
- Titin N2A Domain and Its Interactions at the Sarcomere.International journal of molecular sciences · 2021Review
- mRNA distribution in skeletal muscle is associated with mRNA size.Journal of cell science · 2021Article
- Actin Mutations and Their Role in Disease.International journal of molecular sciences · 2020Review
- Homozygous missense variant in the TTN gene causing autosomal recessive limb-girdle muscular dystrophy type 10.BMC medical genetics · 2019Article
- Characterization of Contractile Proteins from Skeletal Muscle Using Gel-Based Top-Down Proteomics.Proteomes · 2019Review
- Obscurin is a semi-flexible molecule in solution.Protein science : a publication of the Protein Society · 2019Article
- RBM20, a potential target for treatment of cardiomyopathy via titin isoform switching.Biophysical reviews · 2018Review
- Obscure functions: the location-function relationship of obscurins.Biophysical reviews · 2017Review
- A novel FLNC frameshift and an OBSCN variant in a family with distal muscular dystrophy.PloS one · 2017Article
- TheeLife · 2016Article
- Postmortem degradation of skeletal muscle proteins: a novel approach to determine the time since death.International journal of legal medicine · 2016Article
- The biochemical and mass spectrometric profiling of the dystrophin complexome from skeletal muscle.Computational and structural biotechnology journal · 2016Review
- Concurrent Label-Free Mass Spectrometric Analysis of Dystrophin Isoform Dp427 and the Myofibrosis Marker Collagen in Crude Extracts fromProteomes · 2015Article
- Fibre typing of intrafusal fibres.Journal of anatomy · 2015Review
- Molecular investigations into the mechanics of a muscle anchoring complex.Biophysical journal · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Giant muscle proteins (e.g., titin, nebulin, and obscurin) play a seminal role in muscle elasticity, stretch response, and sarcomeric organization. Each giant protein consists of multiple tandem structural domains, usually arranged in a modular fashion spanning 500 kDa to 4 MDa. Although many of the domains are similar in structure, subtle differences create a unique function of each domain. Recent high and low resolution structural and dynamic studies now suggest more nuanced overall protein structures than previously realized. These findings show that atomic structure, interactions between tandem domains, and intrasarcomeric environment all influence the shape, motion, and therefore function of giant proteins. In this article we will review the current understanding of titin, obscurin, and nebulin structure, from the atomic level through the molecular level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.