ArticleFrontiers in behavioral neuroscience2013
Oxytocin receptor ligand binding in embryonic tissue and postnatal brain development of the C57BL/6J mouse.
Article in Frontiers in behavioral neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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72 citing papers in PubMed, 116 citations in OpenAlex.
- Lasting effects of early-life oxytocin treatment on LTP and episodic memory in a mouse model of Fragile X syndrome.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Oxytocin receptor neurons in the paraventricular thalamus as a nexus for social behaviour and fear.Brain : a journal of neurology · 2026Article
- Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Interactive impacts of social deprivation and intranasal oxytocin administration on oxytocin receptor density in prairie vole brains.Frontiers in behavioral neuroscience · 2026Article
- Declines in Oxytocin Receptor Density and Social Behavior Across a Dispersal-Like Transition in Solitary Hamsters.Developmental neurobiology · 2025Article
- Brain serotonin, oxytocin, and their interaction: Relevance for eating disorders.Journal of psychopharmacology (Oxford, England) · 2025Review
- Spatiotemporal Mapping of the Oxytocin Receptor at Single-Cell Resolution in the Postnatally Developing Mouse Brain.Neuroscience bulletin · 2025Article
- Regional differences in three-dimensional fiber organization, smooth muscle cell phenotype, and contractility in the pregnant mouse cervix.Science advances · 2024Article
- Differential temporal decline of cerebral oxytocin and μ-opioid receptor density during the aging process in mice.The European journal of neuroscience · 2024Article
- Role of sexually dimorphic oxytocin receptor-expressing neurons in the anteroventral periventricular nucleus on maternal behavior.Peptides · 2024Review
- Comparative analysis of gonadal hormone receptor expression in the postnatal house mouse, meadow vole, and prairie vole brain.Hormones and behavior · 2024Article
- Lighting up Oxytocin Neurons to Nurture the Brain.Neuroscience bulletin · 2023Article
- Vasopressin receptor 1a, oxytocin receptor, and oxytocin knockout male and female mice display normal perceptual abilities towards non-social odorants.Hormones and behavior · 2023Article
- Oxytocin receptors in the Magel2 mouse model of autism: Specific region, age, sex and oxytocin treatment effects.Frontiers in neuroscience · 2023Article
- The Role of Oxytocin in Abnormal Brain Development: Effect on Glial Cells and Neuroinflammation.Cells · 2022Review
- Oxytocin via oxytocin receptor excites neurons in the endopiriform nucleus of juvenile mice.Scientific reports · 2022Article
- Oxytocin receptor expression patterns in the human brain across development.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Altered PVN-to-CA2 hippocampal oxytocin pathway and reduced number of oxytocin-receptor expressing astrocytes in heart failure rats.Journal of neuroendocrinology · 2022Article
- Oxytocin Receptor-Expressing Neurons in the Paraventricular Thalamus Regulate Feeding Motivation through Excitatory Projections to the Nucleus Accumbens Core.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
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12 more citing papers are in PubMed but not listed here.
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2 authors at 1 institution in 1 country.
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Abstract
unlabelledOxytocin (OXT) has drawn increasing attention as a developmentally relevant neuropeptide given its role in the brain regulation of social behavior. It has been suggested that OXT plays an important role in the infant brain during caregiver attachment in nurturing familial contexts, but there is incomplete experimental evidence. Mouse models of OXT system genes have been particularly informative for the role of the OXT system in social behavior, however, the developing brain areas that could respond to ligand activation of the OXT receptor (OXTR) have yet to be identified in this species. Here we report new data revealing dynamic ligand-binding distribution of OXTR in the developing mouse brain. Using male and female C57BL/6J mice at postnatal days (P) 0, 7, 14, 21, 35, and 60 we quantified OXTR ligand binding in several brain areas which changed across development. Further, we describe OXTR ligand binding in select tissues of the near-term whole embryo at E18.5. Together, these data aid in the interpretation of findings in mouse models of the OXT system and generate new testable hypotheses for developmental roles for OXT in mammalian systems. We discuss our findings in the context of developmental disorders (including autism), attachment biology, and infant physiological regulation. SUMMARY: Quantitative mapping of selective OXTR ligand binding during postnatal development in the mouse reveals an unexpected, transient expression in layers II/III throughout the mouse neocortex. OXTR are also identified in several tissues in the whole late embryo, including the adrenal glands, brown adipose tissue, and the oronasal cavity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.