ArticleFrontiers in cellular neuroscience2013
Optogenetically evoked gamma oscillations are disturbed by cocaine administration.
Article in Frontiers in cellular neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The Effects of Abstinence status and Sleep Quality on Resting State Alpha Power in Cocaine Use Disorder.Clinical EEG and neuroscience · 2026Article
- Novel neurotherapeutic targets for substance use disorders: Neuroplasticity, neuroinflammation, gasotransmitters and non-canonical organ systems.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Perineuronal Nets in the Rat Medial Prefrontal Cortex Alter Hippocampal-Prefrontal Oscillations and Reshape Cocaine Self-Administration Memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Empirical mode decomposition of local field potential data from optogenetic experiments.Frontiers in computational neuroscience · 2023Article
- Arousal-Mediated Sleep Disturbance Persists During Cocaine Abstinence in Male Mice.Frontiers in neuroscience · 2022Article
- Impact of Perineuronal Net Removal in the Rat Medial Prefrontal Cortex on Parvalbumin Interneurons After Reinstatement of Cocaine Conditioned Place Preference.Frontiers in cellular neuroscience · 2022Article
- The Role of Gamma Oscillations in the Pathophysiology of Substance Use Disorders.Journal of personalized medicine · 2020Review
- From Topological Analyses to Functional Modeling: The Case of Hippocampus.Frontiers in computational neuroscience · 2020Article
- Dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice.PloS one · 2019Article
- Hippocampal network oscillations at the interplay between innate anxiety and learned fear.Psychopharmacology · 2019Review
- Cocaine-Induced Changes in Low-Dimensional Attractors of Local Field Potentials in Optogenetic Mice.Frontiers in computational neuroscience · 2018Article
- Article
- Gamma Synchronization Influences Map Formation Time in a Topological Model of Spatial Learning.PLoS computational biology · 2016Article
- Removal of perineuronal nets in the medial prefrontal cortex impairs the acquisition and reconsolidation of a cocaine-induced conditioned place preference memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Low-dimensional attractor for neural activity from local field potentials in optogenetic mice.Frontiers in computational neuroscience · 2015Article
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Authors and funding
5 authors.
Funding
Abstract
Drugs of abuse have enormous societal impact by degrading the cognitive abilities, emotional state and social behavior of addicted individuals. Among other events involved in the addiction cycle, the study of a single exposure to cocaine, and the contribution of the effects of that event to the continuous and further use of drugs of abuse are fundamental. Gamma oscillations are thought to be important neural correlates of cognitive processing in the prefrontal cortex (PFC) which include decision making, set shifting and working memory. It follows that cocaine exposure might modulate gamma oscillations, which could result in reduced cognitive ability. Parvalbumin-positive fast-spiking interneurons play an orchestrating role in gamma oscillation induction and it has been shown recently that gamma oscillations can be induced in an anesthetized animal using optogenetic techniques. We use a knock-in mouse model together with optogenetics and in vivo electrophysiology to study the effects of acute cocaine on PFC gamma oscillation as a step toward understanding the cortical changes that may underlie continuous use of stimulants. Our results show that acute cocaine administration increases entrainment of the gamma oscillation to the optogentically induced driving frequency. Our results also suggest that this modulation of gamma oscillations is driven trough activation of D1 receptors. The acute cocaine-mediated changes in mPFC may underlie the enhancement of attention and awareness commonly reported by cocaine users and may contribute to the further use and abuse of psychostimulants.
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